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製品番号: HY-105801

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Lydimycin

Name: Lydimycin
Brand: MedChemExpress
SKU: HY-105801
Availability: PreOrder

(別名: α-DHB; α-Dehydrobiotin)

Lydimycin (α-DHB; α-Dehydrobiotin) is an antibiotic produced by Streptomyces lydicus, with antibacterial, antifungal and antiviral activities. Lydimycin inhibits the binding of SARS-CoV-2 S-614G spike protein to human ACE2. The antibacterial activity of Lydimycin can be reversed by Biotin (HY-B0511) in the culture medium. Lydimycin is applicable to infection-related research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 10118-85-1
分子式: C₁₀H₁₄N₂O₃S
分子量:242.29

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Lydimycin 構造式

CAS 番号: 10118-85-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

Bacterial^[1]

Antibiotic アイソフォーム固有の製品をすべて表示 :

体外実験

Lydimycin (compound Ⅰ) displays broad-spectrum in vitro antimicrobial activity against diverse gram-positive bacteria, gram-negative bacteria, and fungi^[1].
Lydimycin (1.25-20.0 μg) inhibits Escherichia coli growth in a synthetic medium in a dose-dependent manner, with its antibacterial activity reversed by increasing concentrations of biotin, showing no inhibition at 0.100 μg/mL Biotin (HY-B0511) across all tested doses^[1].
Lydimycin (0-200 μM) inhibits the binding of SARS-CoV-2 S-614G-Strep spike protein to human ACE2-Fc with an IC₅₀ of 1.6 μM, without non-specific Alpha signal interference^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 10118-85-1
分子量 242.29
分子式 C₁₀H₁₄N₂O₃S
SMILES

C(C/C=C/C(O)=O)[C@H]1[C@@]2([C@@](NC(=O)N2)(CS1)[H])[H]
別名

α-DHB; α-Dehydrobiotin
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Microorganisms
Streptomyces lydicus
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Hanka L J, et al. Naturally Occurring Antimetabolite Antibiotic Related to Biotin. Science, 1966, 154(3757): 1667-1668.

[2]. Sammons RM, et al. High-Throughput Assay for Identifying Diverse Antagonists of the Binding Interaction between the ACE2 Receptor and the Dynamic Spike Proteins of SARS-CoV-2. ACS infectious diseases. 2022 Nov 11;8(11):2259-2270. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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生物活性
- 製品説明
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- 体外実験
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参考文献

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Lydimycin

Antibiotic アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC50 & Target

体外実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Lydimycin 関連分類

HY-105801 関連分類

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