Phen-DC3
Based on 12 publication(s) in Google Scholar
Phen-DC3 is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65±6 and 50±10 nM, respectively.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 942936-75-6
- 分子式: C34H26N6O2
- 分子量:550.61
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Phen-DC3
More- Nucleic Acids Res. 2026 Jan 14;54(2):gkaf1481. [Abstract]
- Nucleic Acids Res. 2024 Mar 21;52(5):2142-2156. [Abstract]
- Cell Death Dis. 2021 Oct 25;12(11):999. [Abstract]
- Int J Biol Macromol. 2025 Jun 20;319(Pt 1):145405. [Abstract]
- Int J Biol Macromol. 2025 Mar:296:139582. [Abstract]
- J Mol Med (Berl). 2026 Apr 23;104(1):68. [Abstract]
- iScience. 2026 May 22;29(6):116036.
- iScience. 2022 Oct 9;25(11):105312. [Abstract]
- J Phys Chem B. 2023 Jul 6;127(26):5859-5868. [Abstract]
- Biochem Biophys Res Commun. 2026 Jan 8:795:153117. [Abstract]
- Res Vet Sci. 2026 Jul:206:106188. [Abstract]
- Patent. US20210188889A1.
Customer Validation & Images
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Bio/Physico-chemical Assay
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Cell Proliferation/Viability Assay
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RT-PCR
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Flow Cytometry
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RT-PCR
DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示
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生物活性
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Helicase |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | IC50 |
1.5 nM
Compound: phen-DC3
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Inhibition of human telomerase expressed in HEK293T cells treated before telomerase elongation by telomeric repeat amplification protocol assay
Inhibition of human telomerase expressed in HEK293T cells treated before telomerase elongation by telomeric repeat amplification protocol assay
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[PMID: 17954919] |
| HEK-293T | IC50 |
1500 nM
Compound: phen-DC3
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Inhibition of human telomerase expressed in HEK293T cells in presence of primer TS by primer extension assay
Inhibition of human telomerase expressed in HEK293T cells in presence of primer TS by primer extension assay
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[PMID: 17954919] |
| HEK-293T | IC50 |
2.2 nM
Compound: phen-DC3
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Inhibition of human telomerase expressed in HEK293T cells treated after telomerase elongation by telomeric repeat amplification protocol assay
Inhibition of human telomerase expressed in HEK293T cells treated after telomerase elongation by telomeric repeat amplification protocol assay
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[PMID: 17954919] |
| HEK-293T | IC50 |
63 nM
Compound: phen-DC3
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Inhibition of human telomerase expressed in in HEK293T cells in presence of primer (T2AG3)4 by primer extension assay
Inhibition of human telomerase expressed in in HEK293T cells in presence of primer (T2AG3)4 by primer extension assay
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[PMID: 17954919] |
| HEK-293T | IC50 |
790 nM
Compound: phen-DC3
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Inhibition of human telomerase expressed in HEK293T cells in presence of primer (T2AG3)3 by primer extension assay
Inhibition of human telomerase expressed in HEK293T cells in presence of primer (T2AG3)3 by primer extension assay
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[PMID: 17954919] |
化学情報
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CAS 番号 942936-75-6
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分子量 550.61
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分子式 C34H26N6O2
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SMILES
C[N+]1=C2C=CC=CC2=CC(NC(C3=CC=C4C=CC5=CC=C(C(NC6=C[N+](C)=C7C=CC=CC7=C6)=O)N=C5C4=N3)=O)=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (12)
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Journal Impact Factor
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Most Recent
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Nucleic Acids Res
RNA G-quadruplexes promote codon repeat-associated ribosomal frameshifting in human genes. [Abstract]2026 Jan 14;54(2):gkaf1481. PMID: 41543171 -
Nucleic Acids Res
2024 Mar 21;52(5):2142-2156. PMID: 38340342 -
Cell Death Dis
2021 Oct 25;12(11):999. PMID: 34697294
Phen-DC3 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2021 Oct 25;12(11):999. [Abstract]
The relative enrichment of G-quadruplexes (G4) in Lhcgr CGI-II from TM3 cells treated with vehicle or 10 μM 5-ALA, 5 μM 360 A iodide, or 10 μM Phen-DC3 Trifluoromethanesulfonate (Phen-DC3) (48 h) by ChIP-qPCR analysis. The G-quadruplex antibody (BG4) or IgG were used, respectively. N = 3 for each group.
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Int J Biol Macromol
An RNA G-quadruplex within the sclerostin 3' untranslated region enhances sclerostin expression by blocking miR-4648 binding. [Abstract]2025 Jun 20;319(Pt 1):145405. PMID: 40545075
Phen-DC3 purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2025 Jun 20;319(Pt 1):145405. [Abstract]
FRET-MC profiles were obtained under different experimental conditions: (1) 0.2 μM F21T alone (black line), (2) 0.2 μM F21T with 0.4 μM Phen-DC3 Trifluoromethanesulfonate (PhenDC3) (red line), (3) 0.2 μM F21T with 0.4 μM PhenDC3 and 2 μM SOST RG4wt competitors (blue line), and (4) 0.2 μM F21T with 0.4 μM PhenDC3 and 2 μM SOST RG4mut competitors (purple line). The FRET-MC buffer was composed of 10 mM KCl, 90 mM LiCl, and 10 mM lithium cacodylate at pH 7.2.
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Int J Biol Macromol
2025 Mar:296:139582. PMID: 39798757 -
J Mol Med (Berl)
The role and mechanism of TNFRSF21 in promoting necroptosis of vascular endothelial cells and inducing vascular leakage in sepsis. [Abstract]2026 Apr 23;104(1):68. PMID: 42020785 -
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iScience
Genomic G-quadruplex folding triggers a cytokine-mediated inflammatory feedback loop to aggravate inflammatory diseases. [Abstract]2022 Oct 9;25(11):105312. PMID: 36304116
Phen-DC3 purchased from MedChemExpress. Usage Cited in: iScience. 2022 Oct 9;25(11):105312. [Abstract]
Cell viability was analyzed using a CCK-8 kit under the G4 stabilizer treatment for 12 h, 24 h, and 48 h. Phen-DC3 Trifluoromethanesulfonate (Phen-DC3) (5-100 nM)-induced G4 stabilization inhibited NP cell viability in a dose-dependent manner.
Phen-DC3 purchased from MedChemExpress. Usage Cited in: iScience. 2022 Oct 9;25(11):105312. [Abstract]
mRNA expression of Il6 after the single or combined treatment of PDS, Braco-19, Phen-DC3 Trifluoromethanesulfonate (Phen-DC3) (5-20 nM) and IL-1β (10 ng/mL). Phen-DC3 promoted Il6 mRNA expression in NP cells in a dose-dependent manner by stabilizing genomic G4 structures.
Phen-DC3 purchased from MedChemExpress. Usage Cited in: iScience. 2022 Oct 9;25(11):105312. [Abstract]
Flow cytometry assay for the cell apoptosis under the treatment of PDS, Braco-19, and Phen-DC3 Trifluoromethanesulfonate (Phen-DC3) (5-20 nM).
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J Phys Chem B
Nonselective Intercalation of G-Quadruplex-Targeting Ligands into Double-Stranded DNA Quantified by Single-Molecule Stretching. [Abstract]2023 Jul 6;127(26):5859-5868. PMID: 37357414 -
Biochem Biophys Res Commun
2026 Jan 8:795:153117. PMID: 41380445 -
Res Vet Sci
HnRNP H1 binds to nucleocapsid protein and potential guanine-quadruplex site of viral RNA to promote PRRSV-2 proliferation. [Abstract]2026 Jul:206:106188. PMID: 41996971 -
溶剤 & 溶解度
DMSO : ≥ 34 mg/mL (61.75 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
参考文献
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8162 mL | 9.0808 mL | 18.1617 mL | 45.4042 mL |
| 5 mM | 0.3632 mL | 1.8162 mL | 3.6323 mL | 9.0808 mL | |
| 10 mM | 0.1816 mL | 0.9081 mL | 1.8162 mL | 4.5404 mL | |
| 15 mM | 0.1211 mL | 0.6054 mL | 1.2108 mL | 3.0269 mL | |
| 20 mM | 0.0908 mL | 0.4540 mL | 0.9081 mL | 2.2702 mL | |
| 25 mM | 0.0726 mL | 0.3632 mL | 0.7265 mL | 1.8162 mL | |
| 30 mM | 0.0605 mL | 0.3027 mL | 0.6054 mL | 1.5135 mL | |
| 40 mM | 0.0454 mL | 0.2270 mL | 0.4540 mL | 1.1351 mL | |
| 50 mM | 0.0363 mL | 0.1816 mL | 0.3632 mL | 0.9081 mL | |
| 60 mM | 0.0303 mL | 0.1513 mL | 0.3027 mL | 0.7567 mL |
Phen-DC3 関連分類
HY-15594 関連分類
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