Stigmastanol
Based on 1 publication(s) in Google Scholar
Stigmastanol is a 6-amino derivative. Stigmastanol can be isolated from Hypericum riparium. Stigmastanol increases the secretion of IL-2 and IL-10. Stigmastanol reduces the maximum mitochondrial respiration of cells. Stigmastanol has beneficial effects on the weakened immune function of asthma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.0%
- CAS 番号: 83-45-4
- 分子式: C29H52O
- 分子量:416.72
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 Sitostanol
More
生物活性
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Human Endogenous Metabolite |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| J774 | IC50 |
>240 μM
Compound: 10
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Cytotoxicity against mouse J774 cells by alamar blue assay
Cytotoxicity against mouse J774 cells by alamar blue assay
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[PMID: 17637068] |
Sitostanol (1.2 μM; 24 h) does not alter mitochondrial respiration in human brown adipocytes or human myotubes, but reduces maximal mitochondrial respiration in human hepatocellular carcinoma HepG2 cells cultured in low-glucose medium[3].
Sitostanol (1.2 μM; 48 h for Treg population) increases the secretion of Th1-type cytokines IFN-γ and IL-2, promotes the number of regulatory T cells (Treg) and IL-10 secretion, reduces the proportion of NK cells, and tends to decrease NKT cell activity in phytohaemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMCs) from asthma patients[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 83-45-4
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性状 Solid
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分子量 416.72
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分子式 C29H52O
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Color White to off-white
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SMILES
CC[C@H](CC[C@@H](C)[C@]1([H])[C@]2(C)[C@](CC1)([H])[C@]3([H])CC[C@@]4([H])C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC2)C(C)C
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別名
Stigmastanol; 24α-Ethyl cholestanol
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Structure Classification
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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ACS Nano
Modulating Immunogenicity and Reactogenicity in mRNA-Lipid Nanoparticle Vaccines through Lipid Component Optimization. [Abstract]2025 Aug 5;19(30):27977-28001. PMID: 40700637
溶剤 & 溶解度
Ethanol : 5 mg/mL (12.00 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (480 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Pinhas H, et al. 6-amino derivatives of stigmastanol and cholestanol. J Med Chem. 1971;14(11):1048-1049. [Content Brief]
[2]. Tanemossu SA, et al. Rare biscoumarin derivatives and flavonoids from Hypericum riparium. Phytochemistry. 2014;105:171-177. [Content Brief]
[3]. Nascimento EBM, et al. In vitro effects of sitosterol and sitostanol on mitochondrial respiration in human brown adipocytes, myotubes and hepatocytes. Eur J Nutr. 2020 Aug;59(5):2039-2045. [Content Brief]
[4]. Brüll F, et al. Beneficial effects of sitostanol on the attenuated immune function in asthma patients: results of an in vitro approach. PLoS One. 2012;7(10):e46895. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 2.3997 mL | 11.9985 mL | 23.9969 mL | 59.9923 mL |
| 5 mM | 0.4799 mL | 2.3997 mL | 4.7994 mL | 11.9985 mL | |
| 10 mM | 0.2400 mL | 1.1998 mL | 2.3997 mL | 5.9992 mL |
Sitostanol 関連分類
HY-113494 関連分類
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