D-セリン
Based on 2 publication(s) in Google Scholar
D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration.
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- 純度: 98.0%
- CAS 番号: 312-84-5
- 分子式: C3H7NO3
- 分子量:105.09
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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MedChemExpress（MCE）の使用を引用している文献 D-Serine
MoreiGluR アイソフォーム固有の製品をすべて表示
MoreEndogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
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NMDA Receptor |
Human Endogenous Metabolite |
(R)-Serine is synthesized from L-Ser by serine racemase (SR) and degraded by D-amino acid oxidase (DAAO) and SR. Distribution of D-Ser and NMDAR as determined by chemical measurement and immunohistochemistry supports D-Ser as an endogenous coagonist acting on the glycine modulatory site of the NR1 subunits of the NMDAR[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Four week old male C57Bl/6 mice
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Dosage:10 g/L
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Administration:Oral administration (drinking water supplemented with 10 g/l D-serine); throughout 8 weeks
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Result:Showed strongly reduced weight gain during the first week of supplementation with paralleled weight gain to HFD fed mice, but no catch up thereafter.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 312-84-5
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性状 Solid
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分子量 105.09
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分子式 C3H7NO3
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Color White to off-white
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SMILES
N[C@H](CO)C(O)=O
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別名
D-Serine; (R)-Serine
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
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Front Immunol
Repetitive transcranial magnetic stimulation alleviates neuropathic pain via microglial polarization by modulating the METTL3/NMDAR2B/NLRP3 pathway. [Abstract]2026 Jan 26:16:1666920. PMID: 41668762 -
溶剤 & 溶解度
H2O : ≥ 50 mg/mL (475.78 mM)
Methanol : < 1 mg/mL (insoluble)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (475.78 mM); Clear solution; Need ultrasonic
純度とドキュメンテーション
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取扱説明書 (2659 KB)
参考文献
[1]. Andrea R. Durrant, et al. D-Serine in Neuropsychiatric Disorders: New Advances.
[2]. MacKay MB, et al. D-Serine: Potential Therapeutic Agent and/or Biomarker in Schizophrenia and Depression? Front Psychiatry. 2019 Feb 6;10:25. [Content Brief]
[3]. Dai X, et al. D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep. Nat Commun. 2019 May 7;10(1):1986. [Content Brief]
[4]. Suwandhi L, et al. Chronic d-serine supplementation impairs insulin secretion. Mol Metab. 2018 Oct;16:191-202. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 9.5157 mL | 47.5783 mL | 95.1565 mL | 237.8913 mL |
| 5 mM | 1.9031 mL | 9.5157 mL | 19.0313 mL | 47.5783 mL | |
| 10 mM | 0.9516 mL | 4.7578 mL | 9.5157 mL | 23.7891 mL | |
| 15 mM | 0.6344 mL | 3.1719 mL | 6.3438 mL | 15.8594 mL | |
| 20 mM | 0.4758 mL | 2.3789 mL | 4.7578 mL | 11.8946 mL | |
| 25 mM | 0.3806 mL | 1.9031 mL | 3.8063 mL | 9.5157 mL | |
| 30 mM | 0.3172 mL | 1.5859 mL | 3.1719 mL | 7.9297 mL | |
| 40 mM | 0.2379 mL | 1.1895 mL | 2.3789 mL | 5.9473 mL | |
| 50 mM | 0.1903 mL | 0.9516 mL | 1.9031 mL | 4.7578 mL | |
| 60 mM | 0.1586 mL | 0.7930 mL | 1.5859 mL | 3.9649 mL | |
| 80 mM | 0.1189 mL | 0.5947 mL | 1.1895 mL | 2.9736 mL | |
| 100 mM | 0.0952 mL | 0.4758 mL | 0.9516 mL | 2.3789 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
D-Serine 関連分類
HY-100808 関連分類
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