AA3-DLin
Based on 1 Customer Validation
AA3-DLin is a biodegradable ionizable cationic lipid (pKa = 5.8). AA3-DLin is used to combine mRNA with lipid nanoparticles (LNPs) for delivery, thereby achieving endosomal escape and cytoplasmic release. AA3-DLin can be used in research on type 2 diabetes, steroid-resistant asthma, lung cancer, ischemic stroke, breast cancer, melanoma, and COVID-19.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.0%
- CAS 番号: 3027565-91-6
- 分子式: C44H78N2O4
- 分子量:699.10
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保管条件:
Solution, -20°C, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
The AA3-DLin-based LNP formulation (4 h) demonstrates efficient cellular uptake across LLC, B16F10, and 4T1 cancer cell lines, and this uptake is not altered by nebulization[3].
The AA3-DLin-based LNP formulation (4-48 h) effectively mediates gene transfection and PD-L1 silencing in both murine and human lung cancer cell lines, and this efficacy is preserved after nebulization[3].
The AA3-DLin-based LNP formulation (8-72 h) effectively delivers mscFv to LLC, B16F10, and 4T1 cells, leading to intracellular expression of anti-DDR1 scFv and its sustained secretion[3].
AA3-Dlin LNPs (0.5-4 h) are efficiently internalized by HEK 293, HeLa, 4T1, and B16F10 cells in a time-dependent manner[5].
AA3-Dlin LNPs (0.5 μg/mL; 4 h) facilitate endosomal escape to release mRNA into the cytosol of HEK 293, HeLa, 4T1, and B16F10 cells[5].
The optimized A12 AA3-DLin LNP formulation (0.1 μg; 24 h) demonstrates superior in vitro mRNA transfection efficacy in Hek 293 cells compared to MC3 LNPs, lipofectamine 3000, and ALC-0315 LNPs, with no observed cytotoxicity[6].
AA3-DLin LNPs (72 h) demonstrate excellent mRNA delivery efficiency and can be used for mRNA vaccine development and gene therapy research[8].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 3027565-91-6
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性状 Liquid
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分子量 699.10
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分子式 C44H78N2O4
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Color Light yellow to yellow
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SMILES
CCCCC/C=C\C/C=C\CCCCCCCC(OCCN1CCN(CC1)CCOC(CCCCCCC/C=C\C/C=C\CCCCC)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Solution, -20°C, 2 years
溶剤 & 溶解度
体外:
Ethanol : 50 mg/mL (71.52 mM; Need ultrasonic)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[3]. Hu B, et al. Modulating tumor collagen fiber alignment for enhanced lung cancer immunotherapy via inhaled RNA. Nature communications. 2025 Aug 30;16(1):8120. [Content Brief]
[5]. Li F, et al. mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy. Nature communications. 2023 Jul 15;14(1):4223. [Content Brief]
[6]. Li Z, et al. Enzyme-Catalyzed One-Step Synthesis of Ionizable Cationic Lipids for Lipid Nanoparticle-Based mRNA COVID-19 Vaccines. ACS nano. 2022 Nov 22;16(11):18936-18950. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 1.4304 mL | 7.1521 mL | 14.3041 mL | 35.7603 mL |
| 5 mM | 0.2861 mL | 1.4304 mL | 2.8608 mL | 7.1521 mL | |
| 10 mM | 0.1430 mL | 0.7152 mL | 1.4304 mL | 3.5760 mL | |
| 15 mM | 0.0954 mL | 0.4768 mL | 0.9536 mL | 2.3840 mL | |
| 20 mM | 0.0715 mL | 0.3576 mL | 0.7152 mL | 1.7880 mL | |
| 25 mM | 0.0572 mL | 0.2861 mL | 0.5722 mL | 1.4304 mL | |
| 30 mM | 0.0477 mL | 0.2384 mL | 0.4768 mL | 1.1920 mL | |
| 40 mM | 0.0358 mL | 0.1788 mL | 0.3576 mL | 0.8940 mL | |
| 50 mM | 0.0286 mL | 0.1430 mL | 0.2861 mL | 0.7152 mL | |
| 60 mM | 0.0238 mL | 0.1192 mL | 0.2384 mL | 0.5960 mL |
AA3-DLin 関連分類
HY-159700 関連分類
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