AB25583
Based on 1 publication(s) in Google Scholar
AB25583 is a Polθ helicase (Polθ-hel) small molecule inhibitor, with an IC50 value of 6 nM. AB25583 selectively kills BRCA1/2 deficient cells and works in synergy with Olaparib (HY-10162) in cancer cells carrying pathogenic BRCA1/2 mutations. AB25583 can be used for tumor research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.87%
- CAS 番号: 2565637-94-5
- 分子式: C22H17ClN4O3S
- 分子量:452.91
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Cancer Stem Cells Compound Library
HY-L135
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Highly Selective Inhibitors Library
HY-L158
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
MedChemExpress（MCE）の使用を引用している文献 AB25583
MoreDNA/RNA Synthesis アイソフォーム固有の製品をすべて表示
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生物活性
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Helicase |
AB25583 inhibits ATPase activity of Polθ-hel, inhibits microhomology-mediated end joining (MMEJ) expression, hinders the DNA repair process, thereby leading to DNA damage accumulation, especially in cancer cells with BRCA1/2 deficiency[1].
AB25583 (0-10 μM, 24 h) causes the phosphorylation of γH2AX in MDA-MB-436 cell (BRCA1 KO mutant), inhibits the cell survival of MDA-MB-436, reduces the colony density[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-436
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Concentration:0-10 μM
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Incubation Time:24 h
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Result:Promoted the level of phosphorylated γH2AX.
化学情報
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CAS 番号 2565637-94-5
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性状 Solid
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分子量 452.91
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分子式 C22H17ClN4O3S
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Color White to off-white
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SMILES
ClC1=CC=C(COC2=NN=C(NC(C3=C(C4=CC=CC=C4OC)C=CN=C3)=O)S2)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
DMSO : 125 mg/mL (275.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2079 mL | 11.0397 mL | 22.0794 mL | 55.1986 mL |
| 5 mM | 0.4416 mL | 2.2079 mL | 4.4159 mL | 11.0397 mL | |
| 10 mM | 0.2208 mL | 1.1040 mL | 2.2079 mL | 5.5199 mL | |
| 15 mM | 0.1472 mL | 0.7360 mL | 1.4720 mL | 3.6799 mL | |
| 20 mM | 0.1104 mL | 0.5520 mL | 1.1040 mL | 2.7599 mL | |
| 25 mM | 0.0883 mL | 0.4416 mL | 0.8832 mL | 2.2079 mL | |
| 30 mM | 0.0736 mL | 0.3680 mL | 0.7360 mL | 1.8400 mL | |
| 40 mM | 0.0552 mL | 0.2760 mL | 0.5520 mL | 1.3800 mL | |
| 50 mM | 0.0442 mL | 0.2208 mL | 0.4416 mL | 1.1040 mL | |
| 60 mM | 0.0368 mL | 0.1840 mL | 0.3680 mL | 0.9200 mL | |
| 80 mM | 0.0276 mL | 0.1380 mL | 0.2760 mL | 0.6900 mL | |
| 100 mM | 0.0221 mL | 0.1104 mL | 0.2208 mL | 0.5520 mL |
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