AG6033
AG6033 is a potential novel CRBN modulator. AG6033 suppresses various tumor cells by modulating the interactions between CRBN and various antitumor target proteins. AG6033 can cause GSPT1 and IKZF1 degradation. AG6033 induces CRBN-dependent cytotoxic effect.
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- CAS 番号: 329706-62-9
- 分子式: C30H23N5O4
- 分子量:517.53
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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CRBN |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.853 μM
Compound: AG6033
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Antitumor activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTS assay
Antitumor activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTS assay
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[PMID: 35413617] |
AG6033 (0.064-40 μM, 4 h) has potent inhibition ability against A549[1].
AG6033 (1-10 μM, 24 h) significantly promotes apoptosis of A549 cells in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells[1]
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Concentration:0.064 μM, 0.32 μM, 1.6 μM, 8 μM, and 40 μM
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Incubation Time:4 h
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Result:Exhibited potent inhibitory ability against A549, with an IC50 of 0.853 μM.
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Cell Line:A549 cells[1]
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Concentration:1 μM, 5 μM, 10 μM
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Incubation Time:24 h
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Result:Significantly promoted apoptosis of A549 cells in a dose-dependent manner, and the proportion of late apoptotic cells were 5.39%, 22.0%, and 29.1%, respectively.
化学情報
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CAS 番号 329706-62-9
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分子量 517.53
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分子式 C30H23N5O4
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SMILES
O=C(N/N=C1C(N(CC(NC2=CC=CC=C2)=O)C3=C\1C=CC=C3)=O)C4=CC=CC(NC(C5=CC=CC=C5)=O)=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AG6033 関連分類
HY-143435 関連分類
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