Anabsinthin
Anabsinthin is a dimeric sesquiterpene lactone. Anabsinthin can be found in Artemisia absinthium L. (wormwood). Anabsinthin modulates intracellular calcium levels, mediates anti-inflammatory and antioxidant effects. Anabsinthin inhibits Phorbol 12-myristate 13-acetate (HY-18739)-induced superoxide anion production, increased iNOS and MUC5AC protein expression, and IL-1β transcription upregulation. Anabsinthin can be used for the research of citrus canker.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 6903-12-4
- 分子式: C30H40O6
- 分子量:496.64
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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iNOS |
Anabsinthin (1 mM) increases cytosolic calcium levels in BEAS-2B cells, and this activity is not mediated by hTAS2R46[1].
Anabsinthin (1, 10 μM; 1 h) inhibits PMA-induced superoxide anion production in BEAS-2B cells, and this activity is mediated by hTAS2R46[1].
Anabsinthin (1, 10 μM; 18 h) inhibits PMA-induced iNOS protein expression (but not mRNA expression), MUC5AC protein expression, and IL-1β mRNA expression in BEAS-2B cells, with the inhibitory activity on IL-1β mRNA expression not mediated by hTAS2R46.[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human bronchial epithelial BEAS-2B cells
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Concentration:1, 10 μM
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Incubation Time:18 h
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Result:Significantly prevented PMA-induced up-regulation of IL-1β transcription.
Did not show reverted inhibitory effect when co-treated with 1 μM of the hTAS2R46 antagonist 3β-hydroxydihydrocostunolide.
化学情報
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CAS 番号 6903-12-4
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分子量 496.64
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分子式 C30H40O6
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SMILES
C[C@@]12[C@]34C([C@@](O2)(CC[C@]5([H])[C@]4([H])OC([C@H]5C)=O)C)([H])[C@@](C1)([H])[C@@]6([H])[C@]3([H])C(C)=C7[C@]6([H])[C@@](O)(CC[C@]8([H])[C@]7([H])OC([C@H]8C)=O)C
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Talmon M, et al. Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells. J Nat Prod. 2020 Jun 4;83 (6):1740-1750. [Content Brief]
[2]. Aberham A, et al. Analysis of sesquiterpene lactones, lignans, and flavonoids in wormwood (Artemisia absinthium L.) using high-performance liquid chromatography (HPLC)-mass spectrometry, reversed phase HPLC, and HPLC-solid phase extraction-nuclear magnetic resonance. J Agric Food Chem. 2010;58(20):10817-10823. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Anabsinthin 関連分類
HY-N18053 関連分類
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