Anticancer agent 76
Anticancer agent 76 (Compound CT2-3) is an anticancer agent. Anticancer agent 76 significantly inhibits the proliferation of human NSCLC cells, induces cell cycle arrest, causes ROS generation and induces cell apoptosis.
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- CAS 番号: 2448091-11-8
- 分子式: C32H33NO5S
- 分子量:543.67
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
41.63 μM
Compound: CT2-3
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Antiproliferative activity against human A549 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK-8 assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK-8 assay
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[PMID: 32044229] |
| NCI-H460 | IC50 |
38.03 μM
Compound: CT2-3
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Antiproliferative activity against human H460 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK-8 assay
Antiproliferative activity against human H460 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK-8 assay
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[PMID: 32044229] |
Anticancer agent 76 (Compound CT2-3) (0-80 μM, 24 h) inhibits the proliferation of human NSCLC cells[1].
Anticancer agent 76 (40 μM, 24 h) arrests cell cycle at G1 phase, induces apoptosis and ROS, suppresses the expression of c-Myc and topoisomerases in NSCLC cells [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 and H460
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Concentration:0, 10, 20, 40, 60 and 80 μM
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Incubation Time:24 h
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Result:Inhibited the proliferation with IC50 values of 41.63 μM and 38.03 μM against A549 and H460 cells, respectively.
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Cell Line:H460
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Concentration:40 μM
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Incubation Time:24 h
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Result:Resulted in increasing cell populations at the G1 phase, down-regulated CDK4, CDK6 and cyclin D1.
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Cell Line:A549 and H460
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Concentration:20 μM and 40 μM
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Incubation Time:24 h
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Result:Induced apoptosis.
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Cell Line:H460 cell
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Concentration:40 μM
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Incubation Time:24 h
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Result:Down-regulated mRNA of TOP2B, TOP3B and c-Myc.
化学情報
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CAS 番号 2448091-11-8
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分子量 543.67
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分子式 C32H33NO5S
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SMILES
O=C1N(CCCCS(CCOC2=CC=C(CC=C)C=C2C3=CC(CC=C)=CC=C3O)=O)C(C4=C1C=CC=C4)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Anticancer agent 76 関連分類
HY-150571 関連分類
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