Antimalarial agent 26
Antimalarial agent 26 is an orally active 1,4-naphthoquinones derivative with antimalarial activities. Antimalarial agent 26 shows cytotoxicity against P. falciparum and selectivity over mammalian cell lines. Antimalarial agent 26 inhibits P. burghei induced parasitemia in vivo.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2299199-56-5
- 分子式: C20H22N4O3
- 分子量:366.41
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | CC50 |
440.9 μM
Compound: 11
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Cytotoxicity against human HepG2 cells incubated for 24 hrs by MTT assay
Cytotoxicity against human HepG2 cells incubated for 24 hrs by MTT assay
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[PMID: 37130472] |
| Vero | CC50 |
1336 μM
Compound: 11
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Cytotoxicity against African green monkey Vero cells incubated for 24 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells incubated for 24 hrs by MTT assay
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[PMID: 37130472] |
Antimalarial agent 26 (compound 11) inhibits P. falciparum with IC50 of 2.7 μM, while shows CC50 on mammalian cells with CC50s of 440.9 μM (HepG2), and 1336 μM (Vero), respectively[1].
Antimalarial agent 26 (1000 to 15.62 μM; 2 h) shows hemolytic activity below 40% at concentrations from 250 to 15.6 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Antimalarial agent 26 (300 mg/kg; po; single dose) shows pathological lesions of hepatocellular damage in female mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female albino swiss mice[1]
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Dosage:300 mg/kg
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Administration:PO; single dose
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Result:Presented necrosis of hepatocytes in moderate to severe degrees, acidophilic cytoplasm with macro vacuoles and micro steatosis, granular degeneration and congestion of the lobular center vein and hepatic portal vein.
In the kidney, Resulted an atrophic glomerulus was observed with congested capillaries, reduction of mesangial cells and podocytes with discrete thickening of the basal membrane.
化学情報
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CAS 番号 2299199-56-5
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分子量 366.41
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分子式 C20H22N4O3
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SMILES
O=C1C=C(C(C2=C1C=CC=C2)=O)NCCN3N=NC(C4(CCCCC4)O)=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antimalarial agent 26 関連分類
HY-149939 関連分類
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