AO-022
AO-022 is a potent TALDO1 allosteric inhibitor. AO-022 decreases the expression of vimentin and snail. AO-022 shows antiproliferative activity and antitumor activity. AO-022 has the potential for the research of breast cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C21H16ClNO4S
- 分子量:413.87
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
TALDO1[1]
AO-022 (5, 10, 20, 40, 80 µM; 24 h) inhibits cell viability in a dose-dependent manner in MDA-MB-231 cells[1].
AO-022 (0, 2.5,5, 10, 20 µM; 24 h) decreases the protein expression of vimentin and snail in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 cells
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Concentration:0, 2.5,5, 10, 20 µM
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Incubation Time:24 h
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Result:Inhibited the protein expression of vimentin and snail in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-week-old female nude mice (MDA-MB-231 cells)[1]
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Dosage:50 mg/kg
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Administration:I.p.; every other day for fourteen days
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Result:Significantly reduced tumor volume and tumor weight.
化学情報
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分子量 413.87
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分子式 C21H16ClNO4S
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SMILES
O=C1N(CC2=CC=CS2)C3=C(C=C(Cl)C=C3)[C@]1(O)CC(C4=CC=CC=C4O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Xu G, Huang R, Wumaier R, Lyu J, Huang M, Zhang Y, Chen Q, Liu W, Tao M, Li J, Tao Z, Yu B, Xu E, Wang L, Yu G, Gires O, Zhou L, Zhu W, Ding C, Wang H. Proteomic Profiling of Serum Extracellular Vesicles Identifies Diagnostic Signatures and Therapeutic Targets in Breast Cancer. Cancer Res. 2024 Jun 20. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AO-022 関連分類
HY-159130 関連分類
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