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製品番号: HY-129471

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Arbaprostil

Name: Arbaprostil
Brand: MedChemExpress
SKU: HY-129471
Price: 354.00 USD
Availability: InStock
Rating: 5 (1 reviews)

Arbaprostil is an orally active PGE1 (HY-B0131) analog. Arbaprostil protects the gastrointestinal mucosa from stomach acid and other irritants, promotes healing rate of gastric ucler through the antisecretory effect.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 55028-70-1
分子式: C₂₁H₃₄O₅
分子量:366.49

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Arbaprostil 構造式

CAS 番号: 55028-70-1

容量

価格（税別）

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数量

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Endogenous Metabolite アイソフォーム固有の製品をすべて表示 :

体内実験

Arbaprostil (1-100 μg/kg, i.v., single dose) promotes bicarbonate secrection in dose-dependent manner in proximal duodenum, promotes duodenal healing rates and prevents duodenced mucosa damage in wistar rats^[1].
Arbaprostil (1-100 μg/kg, p.o., single dose) pH-dependently inhibits gastric secretion, promotes the gastric ucler healing (3-10 μg/kg, p.o., twice daily for 4 weeks) in Donryu rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar rat^[1]
Dosage:

1-100 μg/kg
Administration:

i.v., single dose
Result:

Increased secrection of HCO₃⁺.

Animal Model:

Donryu rats^[2]
Dosage:

1-100 μg/kg
Administration:

1-100 μg/kg, p.o. and i.d. (intraduodenally), single dose; 3-10 μg/kg, p.o., twice daily for 4 weeks
Result:

Inhibited the gastric secretion when intraduodenally administrated.
Increased the gastric secretion when orally administrated.
Accelerated the healing rate of gastric ucler.

化学情報

CAS 番号 55028-70-1
分子量 366.49
分子式 C₂₁H₃₄O₅
SMILES

CCCCC[C@@](O)(/C=C/[C@H]1[C@@H](CC([C@@H]1C/C=C\CCCC(O)=O)=O)O)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (275 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Li JY, Nagata T, Yoshida M, Yagi N, Katoh K, Haramoto T, Itoh K, Iwasaki A, Matsuo Y. Effect of 15(R)-15-methyl PGE2 (arbaprostil) on duodenal bicarbonate secretion in rat. Gastroenterol Jpn. 1989 Feb;24(1):8-11. [Content Brief]

[2]. Okabe S, et al., Effects of 15(R)-15-methyl prostaglandin E2 (arbaprostil) on gastric secretion and various gastric lesions induced in rats. Jpn J Pharmacol. 1986 Feb;40(2):329-37. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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