AS1-6
AS1-6 is a selective COX-2 inhibitor with an IC50 of 2.7 μM. AS1-6 has an IC50 of 12.6 μM for COX-1. AS1-6 exerts significant anti-inflammatory and analgesic activities. AS1-6 can be used in research on non-steroidal anti-inflammatory agents.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C23H17ClFNO3
- 分子量:409.84
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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COX-2 2.7 μM (IC50) |
COX-1 12.6 μM (IC50) |
AS1-6 (10-200 μg/mL; 24 h) shows low toxicity to brine shrimp, with an LD50 > 200 μg/mL[1].
AS1-6 (30 μg/mL; 24-48 h) shows no activity against 3T3 fibroblasts, indicating its low toxicity toward non-cancerous cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Albino mice (adult male and female, 6-7 weeks old, 25-30 g)[1]
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Dosage:10 mg/kg
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Administration:i.p.; single dose
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Result:Significantly reduced paw thickness to 4.00 mm and COX-2 protein levels in the carrageenan-induced paw edema model.
Remarkably suppressed nociceptive behaviors in both the early phase and late phase, indicating both peripheral and central antinociceptive activity in formalin-induced paw licking test.
Significantly decreased the number of writhing responses in the acetic acid-induced writhing test.
化学情報
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分子量 409.84
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分子式 C23H17ClFNO3
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SMILES
O=C(NC1=CC=C(F)C=C1)COC2=CC=C(C(/C=C/C3=CC=CC=C3Cl)=O)C=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AS1-6 関連分類
HY-181123 関連分類
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