Astin C
Based on 1 Customer Validation
Astin C (Asterin) is a cyclopeptide that can be extracted from Aster tataricus. Astin C has anti-inflammatory and anti-cancer activities. Astin C can specifically inhibit the cGAS-STING signaling pathway, block the recruitment of IRF3 to the STING signalosome, and thus inhibit the innate inflammatory response. Astin C can be used in the research of autoimmune diseases and cancers.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.47%
- CAS 番号: 148057-23-2
- 分子式: C25H33Cl2N5O6
- 分子量:570.47
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Astin C (10 μM; 6 h) significantly inhibits the expression of Ifnb mRNA induced by cGAS or STING in HEK293 cells[1].
Astin C (10 μM; 6 h) significantly impaires the interactions between STING and IRF3, as well as between STING and SCAP, and inhibits the aggregation of SCAP and IRF3 in HEK293T cells and MEFs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293 treated cGAS or STING
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Concentration:10 μM
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Incubation Time:6 h
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Result:Inhibited the mRNA level of Ifnb.
体内実験
Astin C (5.0 mg/kg; intraperitoneal injection; 5 days) achieves a tumor growth inhibition rate of 45% in male ICR mice inoculated with Sarcoma 180 ascites tumor[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Trex1-/- mice[1]
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Dosage:2 and 4 mg/kg
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Administration:Tail vein injection; once every 2 days; 7 days
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Result:Inhibited the expression of type I interferon and pro-inflammatory cytokines in Trex1-/- BMDMs.
Alleviated autoimmune inflammatory symptoms, decreased the abundance of sera autoantibodies, and reduced the percentage of activated CD8+ T cells in the spleen.
化学情報
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CAS 番号 148057-23-2
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性状 Solid
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分子量 570.47
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分子式 C25H33Cl2N5O6
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Color Off-white to yellow
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別名
Asterin
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配列
Cyclo({Abu}-Pro-{Abu}-Ser-{Oaa})
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シーケンスの短縮
Cyclo({Abu}-P-{Abu}-S-{Oaa})
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (175.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Li S, et al. The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING. Cell Rep. 2018 Dec 18;25(12):3405-3421.e7. [Content Brief]
[2]. Antoine Vassaux, et al. Astin C Production by the Endophytic Fungus Cyanodermella asteris in Planktonic and Immobilized Culture Conditions. Biotechnol J. 2019 Aug;14(8):e1800624. [Content Brief]
[3]. Morita H, et al. Cyclic peptides from higher plants. XXVIII. Antitumor activity and hepatic microsomal biotransformation of cyclic pentapeptides, astins, from Aster tataricus. Chem Pharm Bull (Tokyo). 1996 May;44(5):1026-32. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7529 mL | 8.7647 mL | 17.5294 mL | 43.8235 mL |
| 5 mM | 0.3506 mL | 1.7529 mL | 3.5059 mL | 8.7647 mL | |
| 10 mM | 0.1753 mL | 0.8765 mL | 1.7529 mL | 4.3824 mL | |
| 15 mM | 0.1169 mL | 0.5843 mL | 1.1686 mL | 2.9216 mL | |
| 20 mM | 0.0876 mL | 0.4382 mL | 0.8765 mL | 2.1912 mL | |
| 25 mM | 0.0701 mL | 0.3506 mL | 0.7012 mL | 1.7529 mL | |
| 30 mM | 0.0584 mL | 0.2922 mL | 0.5843 mL | 1.4608 mL | |
| 40 mM | 0.0438 mL | 0.2191 mL | 0.4382 mL | 1.0956 mL | |
| 50 mM | 0.0351 mL | 0.1753 mL | 0.3506 mL | 0.8765 mL | |
| 60 mM | 0.0292 mL | 0.1461 mL | 0.2922 mL | 0.7304 mL | |
| 80 mM | 0.0219 mL | 0.1096 mL | 0.2191 mL | 0.5478 mL | |
| 100 mM | 0.0175 mL | 0.0876 mL | 0.1753 mL | 0.4382 mL |
Astin C 関連分類
HY-P1680 関連分類
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