AZD-1305
AZD-1305 is an antiarrhythmic agent and atrial selective sodium channel/potassium channel blocker, which can significantly prolongs action potential duration and reduces excitability, cause atrial selective ERP prolongation and acute termination of atrial fibrillation. AZD1305 can be used for atrial fibrillation research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 872045-91-5
- 分子式: C22H31FN4O4
- 分子量:434.50
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
AZD-1305 (1,3 μM) induces atrial selective PRR in isolated coronary-perfused preparations [1].
AZD-1305 (1,3 μM) produces a greater use-dependent reduction of maximum rate of rise of the action potential upstroke (Vmax) in atrial versus ventricular preparations[1].
AZD-1305 (1,3 μM) causes a greater increase in sodium channel–mediated parameters conduction velocity and diastolic threshold of excitation in atrial versus ventricular coronaryperfused preparations[1].
AZD-1305 (5 μM) induces greater tonic and steadystate inhibitions of atrial sodium channels than ventricular sodium channels in isolated coronary-perfused preparations[1].
AZD-1305 (1-10 μM) causes a significant decrease in Vmax, action potential amplitude, and takeoff potential in canine pulmonary vein sleeve preparations, and significantly increases action potential duration at 90% repolarization[2].
AZD-1305 (1-10 μM) significantly increases the basic cycle length at which 1:1 activation is maintained in canine pulmonary vein sleeve preparations, and pretreatment with amiodarone significantly potentiates the effect of AZD1305[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
AZD-1305 (steady state plasma concentrations of 1.2 and 4.5 μM, i.v.drip) increases conduction time and depress excitability in atria versus ventricles of Beagle dogs [1].
AZD-1305 (steady state plasma concentrations of 1-3 μM, i.v.drip) terminates persistent AF and prevents induction of AF in an ACh-mediated model of AF in Beagle dogs [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 872045-91-5
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分子量 434.50
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分子式 C22H31FN4O4
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SMILES
O=C(OC(C)(C)C)NCCN1CC(O2)CN(CCOC3=CC=C(C#N)C=C3F)CC2C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Charles Antzelevitch, et al. AZD1305 Exerts Atrial Predominant Electrophysiological Actions and Is Effective in Suppressing Atrial Fibrillation and Preventing Its Reinduction in the Dog. [J] Cardiovasc Pharmacol. 2010, Volume 56，Number 1. [Content Brief]
[2]. Serge Sicouri, et al. Electrophysiologic and antiarrhythmic effects of AZD1305 in canine pulmonary vein sleeves. THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2010, Volume 334，Number 1. [Content Brief]
[3]. Alexander Burashnikov, et al. AZD1305 exerts atrial predominant electrophysiological actions and is effective in suppressing atrial fibrillation and preventing its reinduction in the dog. J Cardiovasc Pharmacol. 2010 Jul;56(1):80-90. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AZD-1305 関連分類
HY-111245 関連分類
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