BAY-4931
Based on 1 publication(s) in Google Scholar
BAY-4931 is a potent, covalent and selective PPARγ inverse-agonist with an IC50 of 0.17 nM.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.72%
- CAS 番号: 423150-91-8
- 分子式: C22H16ClN3O4
- 分子量:421.83
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 BAY-4931
More
生物活性
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PPAR-γ 0.17 nM (IC50, RT112-FABP4-NLucP cellular reporter assay) |
mouse PPARγ 0.14 nM (IC50, GAL4-NHR-LBD one hybrid reporter assay ) |
hPPARγ 0.40 nM (IC50, GAL4-NHR-LBD one hybrid reporter assay ) |
BAY-4931 (0-10 μM; 7 days) inhibits UM-UC-9 proliferation with an IC50 of 3.4 nM[1].
BAY-4931 only inhibits CYP2C8 in CYP inhibition test[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:UM-UC-9 cells
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Concentration:0-10 μM
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Incubation Time:7 days
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Result:Inhibited proliferation with an IC50 of 3.4 nM.
化学情報
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CAS 番号 423150-91-8
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性状 Solid
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分子量 421.83
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分子式 C22H16ClN3O4
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Color Light yellow to light brown
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SMILES
O=C(NC1=CC=C(OC(C2=CC=C(CC)C=C2)=N3)C3=C1)C4=CC([N+]([O-])=O)=CC=C4Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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bioRxiv
Structural basis of PPARγ-mediated transcriptional repression by the covalent inverse agonist FX-909. [Abstract]2025 May 8:2025.05.04.651770. PMID: 40654962
溶剤 & 溶解度
DMSO : 125 mg/mL (296.33 mM; ultrasonic and warming and heat to 70°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3706 mL | 11.8531 mL | 23.7062 mL | 59.2656 mL |
| 5 mM | 0.4741 mL | 2.3706 mL | 4.7412 mL | 11.8531 mL | |
| 10 mM | 0.2371 mL | 1.1853 mL | 2.3706 mL | 5.9266 mL | |
| 15 mM | 0.1580 mL | 0.7902 mL | 1.5804 mL | 3.9510 mL | |
| 20 mM | 0.1185 mL | 0.5927 mL | 1.1853 mL | 2.9633 mL | |
| 25 mM | 0.0948 mL | 0.4741 mL | 0.9482 mL | 2.3706 mL | |
| 30 mM | 0.0790 mL | 0.3951 mL | 0.7902 mL | 1.9755 mL | |
| 40 mM | 0.0593 mL | 0.2963 mL | 0.5927 mL | 1.4816 mL | |
| 50 mM | 0.0474 mL | 0.2371 mL | 0.4741 mL | 1.1853 mL | |
| 60 mM | 0.0395 mL | 0.1976 mL | 0.3951 mL | 0.9878 mL | |
| 80 mM | 0.0296 mL | 0.1482 mL | 0.2963 mL | 0.7408 mL | |
| 100 mM | 0.0237 mL | 0.1185 mL | 0.2371 mL | 0.5927 mL |
BAY-4931 関連分類
HY-148352 関連分類
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