BCL6 PROTAC 1
BCL6 PROTAC 1 is a selective B-cell lymphoma 6 (BCL6) PROTAC. BCL6 PROTAC 1 inhibits BCL6 cell reporter with an IC50 value of 8.8 µM. BCL6 PROTAC 1 significantly degrades BCL6 in diffuse large B-cell lymphoma (DLBCL) cell lines. BCL6 PROTAC 1 can be used in tumor related research.
(Pink: BCL6 ligand (HY-176382); Blue: Cereblon ligand (HY-10984); Black: linker (HY-176383)).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2257479-54-0
- 分子式: C45H52ClN9O12
- 分子量:946.40
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
PROTACs アイソフォーム固有の製品をすべて表示
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生物活性
B-cell lymphoma 6, BCL6[1]
BCL6 PROTAC 1 (Compound 15)(0.0001-10 µM; 1-72 h) degrades B-cell lymphoma 6 (BCL6) with dose-dependent manner in OCI-Ly1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:OCI-Ly1 cells.
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Concentration:1 µM.
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Incubation Time:16 d.
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Result:Had no effect on cell viability.
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Cell Line:OCI-Ly1 cells.
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Concentration:0.0001, 0.001, 0.01, 0.1, 0.2, 1, 3, 5 and 10 µM.
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Incubation Time:1, 2, 4, 6, 8, 10, 24, 48, 72 h.
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Result:Degraded BCL6.
化学情報
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CAS 番号 2257479-54-0
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分子量 946.40
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分子式 C45H52ClN9O12
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SMILES
O=C(N1)C(N2C(C(C(OCCOCCOCCCNC(CCC(N3CCN(C4=NC=C(Cl)C(N5)=N4)[C@@H](COCCOC6=CC5=CC(CC7)=C6N(C)C7=O)C3)=O)=O)=CC=C8)=C8C2=O)=O)CCC1=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BCL6 PROTAC 1 関連分類
HY-122829 関連分類
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