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製品番号: HY-147915

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Benz-AP

Benz-AP is a potent photosensitizer. Benz-AP produces singlet oxygen, with a negative correlation with hCES2 (Human carboxylesterase 2) activity. Benz-AP displays a higher photocytotoxicity potency in cancer cells under low hCES2 environments. Upon TPE (Two-photon excitation), Benz-AP produces ROS and kills cancer cells and tumor spheroids.

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CAS 番号: 2416220-53-4
分子式: C₂₀H₁₃NO₂
分子量:299.32

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Benz-AP 構造式

CAS 番号: 2416220-53-4

容量

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Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Carboxylesterase (CES) アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	>32 μM Compound: Benz-AP	Dark toxicity against human A549 cells assessed as reduction in cell viability after 3 hrs by MTT assay Dark toxicity against human A549 cells assessed as reduction in cell viability after 3 hrs by MTT assay	[PMID: 35700557]
A549	CC₅₀	4.4 μM Compound: Benz-AP	Phototoxicity against human A549 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay Phototoxicity against human A549 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay	[PMID: 35700557]
HepG2	CC₅₀	>32 μM Compound: Benz-AP	Dark toxicity against human HepG2 cells assessed as reduction in cell viability after 3 hrs by MTT assay Dark toxicity against human HepG2 cells assessed as reduction in cell viability after 3 hrs by MTT assay	[PMID: 35700557]
HepG2	CC₅₀	>32 μM Compound: Benz-AP	Phototoxicity against human HepG2 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay Phototoxicity against human HepG2 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay	[PMID: 35700557]
MCF7	CC₅₀	>32 μM Compound: Benz-AP	Dark toxicity against human MCF7 cells assessed as reduction in cell viability after 3 hrs by MTT assay Dark toxicity against human MCF7 cells assessed as reduction in cell viability after 3 hrs by MTT assay	[PMID: 35700557]
MCF7	CC₅₀	1.6 μM Compound: Benz-AP	Phototoxicity against human MCF7 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay Phototoxicity against human MCF7 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay	[PMID: 35700557]
PANC-1	CC₅₀	>32 μM Compound: Benz-AP	Dark toxicity against human PANC-1 cells assessed as reduction in cell viability after 3 hrs by MTT assay Dark toxicity against human PANC-1 cells assessed as reduction in cell viability after 3 hrs by MTT assay	[PMID: 35700557]
PANC-1	CC₅₀	0.647 μM Compound: Benz-AP	Induction of cell death in human PANC-1 cells assessed as reduction in cell viability preincubated for 2 hrs followed by compound washout and immediate 900 nm light irradiation and measured 1 hr post light irradiation by two-photon based ReadyProbes blue/ Induction of cell death in human PANC-1 cells assessed as reduction in cell viability preincubated for 2 hrs followed by compound washout and immediate 900 nm light irradiation and measured 1 hr post light irradiation by two-photon based ReadyProbes blue/	[PMID: 35700557]
PANC-1	CC₅₀	0.647 μM Compound: Benz-AP	Induction of cell death in human PANC-1 cells assessed as reduction in cell viability preincubated for 3 hrs followed by compound washout and immediate 900 nm light irradiation and measured 1 hr post light irradiation by two-photon based MTT assay Induction of cell death in human PANC-1 cells assessed as reduction in cell viability preincubated for 3 hrs followed by compound washout and immediate 900 nm light irradiation and measured 1 hr post light irradiation by two-photon based MTT assay	[PMID: 35700557]
PANC-1	CC₅₀	1.4 μM Compound: Benz-AP	Phototoxicity against human PANC-1 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay Phototoxicity against human PANC-1 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay	[PMID: 35700557]

化学情報

CAS 番号 2416220-53-4
分子量 299.32
分子式 C₂₀H₁₃NO₂
SMILES

O=C(NC1=C2C=CC=C3C(C=CC(C=C1)=C32)=O)C4=CC=CC=C4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Kailass K, et al. Two-Photon Photodynamic Therapy Targeting Cancers with Low Carboxylesterase 2 Activity Guided by Ratiometric Fluorescence. J Med Chem. 2022 Jun 14. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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生物活性
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化学情報
純度とドキュメンテーション
参考文献

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Benz-AP

Carboxylesterase (CES) アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Benz-AP 関連分類

HY-147915 関連分類