BMVC
Based on 1 publication(s) in Google Scholar
BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor with an IC50 of ~0.2 μM. BMVC inhibits Taq DNA polymerase with an IC50 of ~2.5 μM. BMVC increases the melting temperature of G4 structure of telomere and accelerates telomere length shortening. Anticancer activities.
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- 純度: 98.40%
- CAS 番号: 627810-06-4
- 分子式: C28H25I2N3
- 分子量:657.33
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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MedChemExpress（MCE）の使用を引用している文献 BMVC
MoreDNA/RNA Synthesis アイソフォーム固有の製品をすべて表示
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生物活性
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DNA Polymerase |
BMVC (0.5 μM; 0-18 days; H1299 cells) treatment markedly increases the percentage of sub-G1-phase cells after 18 days[1].
BMVC (0.5 μM; 0-18 days; H1299 cells) long-term treatment leads to ceasing of cell growth and eventually cell death through apoptosis. The long-term BMVC treatment induces senescence program in H1299 cells[1].
In BMVC-treated cancer cells, hallmarks of senescence, including morphologic changes, detection of senescence-associated β-galactosidase activity, and decreasesd bromodeoxyuridine incorporation, are detected. The BMVC-induced senescence phenotype is accompanied by progressive telomere shortening and detection of the DNA damage foci, indicating that BMVC caused telomere uncapping after long-term treatments[1].
BMVC also suppresses the tumor-related properties of cancer cells, including cell migration, colony-forming ability, and anchorage-independent growth[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:H1299 cells
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Concentration:0.5 μM
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Incubation Time:0 day, 6 days, 12 days, 18 days
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Result:The percentage of sub-G1-phase cells was markedly increased after 18 days.
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Cell Line:H1299 cells
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Concentration:0.5 μM
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Incubation Time:0 day, 6 days, 12 days, 18 days
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Result:Increased apoptotic cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/cAnN.Cg-Foxn1nu/CrlNarl mice injected with H1299 cells[1]
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Dosage:1 mg/kg
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Administration:Intraperitoneal injection; every 3 day
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Result:The growth rates of tumors in animals were significantly slower than that of control animals. The tumor cells of the mice were indeed entering apoptosis.
化学情報
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CAS 番号 627810-06-4
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性状 Solid
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分子量 657.33
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分子式 C28H25I2N3
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Color Orange to red
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SMILES
C[N+]1=CC=C(/C=C/C2=CC3=C(C=C2)NC4=C3C=C(/C=C/C5=CC=[N+](C)C=C5)C=C4)C=C1.[I-].[I-]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Nucleic Acids Res
Regulation of PDGFR-β gene expression by targeting the G-vacancy bearing G-quadruplex in promoter. [Abstract]2021 Dec 16;49(22):12634-12643. PMID: 34850916
溶剤 & 溶解度
DMSO : 10 mg/mL (15.21 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5213 mL | 7.6065 mL | 15.2131 mL | 38.0326 mL |
| 5 mM | 0.3043 mL | 1.5213 mL | 3.0426 mL | 7.6065 mL | |
| 10 mM | 0.1521 mL | 0.7607 mL | 1.5213 mL | 3.8033 mL | |
| 15 mM | 0.1014 mL | 0.5071 mL | 1.0142 mL | 2.5355 mL |
BMVC 関連分類
HY-135775 関連分類
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