BPC 157 acetate
Based on 1 Customer Validation
BPC 157 acetate is an orally active peptide. BPC 157 acetate exhibits multiple activities such as promoting wound healing, tendon healing, neuroprotection, and gastrointestinal protection. BPC 157 acetate can be used in the research of tendon injury, burn, gastric ulcer, and neurological diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.84%
- CAS 番号: 1628202-19-6
- 分子式: C62H98N16O22.xC2H4O2
- 分子量:1419.54 (free acid)
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
BPC 157 (acetate) (2 μg/mL; 7 days) significantly accelerates the outgrowth of tendon fibroblasts from Sprague-Dawley rat Achilles tendon explants[1].
BPC 157 (acetate) (2 μg/mL; 24 h) significantly increases the viability of Sprague-Dawley rat Achilles tendon fibroblasts cultured under oxidative stress induced by 0.1 mM H2O2[1].
BPC 157 (acetate) (0.5–2 μg/mL; 24 h) promotes the migration of cultured Sprague-Dawley rat Achilles tendon fibroblasts and induces increased F-actin formation[1].
BPC 157 (acetate) (0–2 μg/mL; 24 h) activates the FAK-paxillin pathway in cultured SD rat Achilles tendon fibroblasts[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Cultured Sprague-Dawley rat Achilles tendon fibroblasts (passages 2-4)
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Concentration:2 μg/mL
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Incubation Time:24 h
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Result:Increased F-actin (polymerized actin fibers, visualized as green fluorescence) levels notably relative to control cells with weak F-actin detection.
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Cell Line:Cultured Sprague-Dawley rat Achilles tendon fibroblasts (passages 2-4)
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Concentration:0, 0.5, 1, 2 μg/mL
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Incubation Time:24 h
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Result:Did not alter total FAK, paxillin, or PCNA protein levels.
Increased the phosphorylation of both FAK and paxillin dose-dependently.
BPC 157 (acetate) (100 pg-10 μg/kg; i.p.; single dose) significantly alleviates haloperidol (HY-14538)-induced catalepsy in rats and inhibits gastric ulcers[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NMRI-Hannover (male, 30 g, deep partial skin thickness burns induced by 5 s direct flame exposure covering 20% total body area)[2]
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Dosage:i.p.: 10 ng/kg, 10 μg/kg; Topical: 5 ng/g, 50 ng/g, 500 ng/g, 5 μg/g, 50 μg/g
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Administration:topical (burn site, once daily); i.p. (once daily); starting immediately after burn and continuing until 24 hours before sacrifice
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Result:Improved all parameters related to burn wound healing (including reducing edema, inflammatory cell infiltration and necrosis, increasing the number of capillaries, reticulin and collagen fiber formation, preserving hair follicle count, enhancing wound re-epithelization rate, skin breaking strength and relative elongation, and decreasing water content in burned skin).
Consistently attenuates burn-induced gastric mucosal lesions in the deep partial-thickness burn model of male NMRI-Hannover mice.
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Animal Model:Wistar Albino (male, 200-220 g body weight)[3]
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Dosage:10 μg/kg, 10 ng/kg (catalepsy and gastric ulcers); 1.0 ng/kg, 100 pg/kg (gastric ulcers only)
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Administration:i.p.; single dose
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Result:Reduced catalepsy duration on both horizontal bar and inclined wiremesh screen tests at all assessed time points.
Inhibited gastric lesion development for all doses, with near-zero mean sum of lesion diameters and drastically reduced lesion incidence compared to controls.
化学情報
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CAS 番号 1628202-19-6
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性状 Solid
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分子量 1419.54 (free acid)
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分子式 C62H98N16O22.xC2H4O2
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Color White to off-white
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配列
Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
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シーケンスの短縮
GEPPPGKPADDAGLV
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
純度とドキュメンテーション
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データシート (279 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Chang CH, et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol (1985). 2011;110(3):774-780. [Content Brief]
[2]. Mikus D, et al. Pentadecapeptide BPC 157 cream improves burn-wound healing and attenuates burn-gastric lesions in mice. Burns. 2001;27(8):817-827. [Content Brief]
[3]. Jelovac N, et al. Pentadecapeptide BPC 157 attenuates disturbances induced by neuroleptics: the effect on catalepsy and gastric ulcers in mice and rats. Eur J Pharmacol. 1999;379(1):19-31. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BPC 157 acetate 関連分類
HY-105174A 関連分類
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