C24-Ceramide
Based on 1 Customer Validation
C24-Ceramide is an orally active competitive binding agonist of PIP4K2C (mTOR complex regulator), thereby activating the mTOR signaling pathway. At the same time, C24-Ceramide changes the membrane morphology by inducing the formation of a partially interlocked gel phase in the phospholipid bilayer. C24-Ceramide can promote the proliferation and migration of keratinocytes to accelerate skin wound healing and drive the proliferation and metastasis of gallbladder cancer cells. The level of C24-Ceramide in serum can be used as a diagnostic marker for gallbladder cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.92%
- CAS 番号: 34435-05-7
- 分子式: C42H83NO3
- 分子量:650.11
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
189.4 μM
Compound: 2
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Anticancer activity against human HepG2 cells assessed as reduction in cell survival
Anticancer activity against human HepG2 cells assessed as reduction in cell survival
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[PMID: 38086468] |
C24-Ceramide (100 μg/mL; 48 h) significantly promotes cell proliferation and migration in human keratinocytes (HaCaT)[2].
C24-Ceramide (500 μg/mL; 24 h) activates AKT and ERK1/2 signaling pathways[2].
C24-Ceramide (100 nM; 12 h) promotes cell proliferation and migration in gallbladder cancer cells (GBC-SD, NOZ) by binding to PIP4K2C and activating mTOR signaling, while C6-Ceramide competitively inhibited this effect[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
C24-Ceramide (10 mg/kg; dietary supplementation; once daily; 3 weeks) promotes the growth of gallbladder cancer (GBC-SD cells) in a nude mouse subcutaneous xenograft tumor model, as evidenced by increased tumor volume, weight, and the proportion of Ki-67 positive cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male HR-1 hairless mice (6-week-old, 18-20 g), full-thickness skin wound model[2]
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Dosage:4.4 μg C24-Ceramide per dose (formulated as C24-LNP in deionized water)
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Administration:Topical application (10 μL of 1 mg/mL C24-LNP) daily for 10 days
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Result:Significantly accelerated wound closure.
Enhanced re-epithelialization, increased fibroblast proliferation, and improved collagen deposition in the dermis, as confirmed by Masson’s trichrome staining.
Activated AKT and ERK1/2 signaling pathways in wound tissues, promoting cell proliferation and migration.
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Animal Model:Nude mice subcutaneous xenograft model with GBC-SD cells[3]
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Dosage:10 mg/kg
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Administration:Daily oral administration via dietary addition for 3 consecutive weeks
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Result:Significantly increased tumor size and Ki-67 reactivity in xenograft sections, indicating enhanced cell proliferation.
Promoted hepatic metastasis, with higher incidence and size of metastatic lesions compared to control.
Activated mTOR signaling through binding to PIP4K2C, which was antagonized by C6-Ceramide co-treatment.
化学情報
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CAS 番号 34435-05-7
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性状 Solid
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分子量 650.11
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分子式 C42H83NO3
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Color White to off-white
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SMILES
CCCCCCCCCCCCCCCCCCCCCCCC(N[C@@H](CO)[C@H](O)/C=C/CCCCCCCCCCCCC)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
THF : 25 mg/mL (38.46 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : < 1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Ventura AE, et al. Lipid domain formation and membrane shaping by C24-ceramide. Biochim Biophys Acta Biomembr. 2020 Oct 1;1862(10):183400. [Content Brief]
[2]. Lee JH, et al. C24 Ceramide Lipid Nanoparticles for Skin Wound Healing. Pharmaceutics. 2025 Feb 12;17(2):242. [Content Brief]
[3]. Zhang Y, et al. C24-Ceramide Drives Gallbladder Cancer Progression Through Directly Targeting Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Gamma to Facilitate Mammalian Target of Rapamycin Signaling Activation. Hepatology. 2021 Feb;73(2):692-712. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| THF | 1 mM | 1.5382 mL | 7.6910 mL | 15.3820 mL | 38.4550 mL |
| 5 mM | 0.3076 mL | 1.5382 mL | 3.0764 mL | 7.6910 mL | |
| 10 mM | 0.1538 mL | 0.7691 mL | 1.5382 mL | 3.8455 mL | |
| 15 mM | 0.1025 mL | 0.5127 mL | 1.0255 mL | 2.5637 mL | |
| 20 mM | 0.0769 mL | 0.3846 mL | 0.7691 mL | 1.9228 mL | |
| 25 mM | 0.0615 mL | 0.3076 mL | 0.6153 mL | 1.5382 mL | |
| 30 mM | 0.0513 mL | 0.2564 mL | 0.5127 mL | 1.2818 mL |
C24-Ceramide 関連分類
HY-134508 関連分類
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