CBT-295
Based on 1 Customer Validation
CBT-295 is an orally active autotaxin (ATX) inhibitor. CBT-295 exhibits a significant reduction in inflammatory cytokines like TGF-β, TNF-α and IL-6 levels, also reduced bile duct proliferation marker CK-19 and lowered liver fibrosis. The reversal of liver fibrosis with CBT-295 led to a reduction in blood and brain ammonia levels. CBT-295 also reduced neuroinflammation induced by ammonia. CBT-295 is promising for research of liver cirrhosis and associated encephalopathy.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.34%
- CAS 番号: 1623794-90-0
- 分子式: C18H20ClN3O
- 分子量:329.82
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保管条件:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
化学情報
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CAS 番号 1623794-90-0
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性状 Solid
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分子量 329.82
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分子式 C18H20ClN3O
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Color White to off-white
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SMILES
O=C1C=C(C)N(CCCCC)C2=NC(C3=CC=C(Cl)C=C3)=CN12
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
DMSO : 50 mg/mL (151.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0320 mL | 15.1598 mL | 30.3196 mL | 75.7989 mL |
| 5 mM | 0.6064 mL | 3.0320 mL | 6.0639 mL | 15.1598 mL | |
| 10 mM | 0.3032 mL | 1.5160 mL | 3.0320 mL | 7.5799 mL | |
| 15 mM | 0.2021 mL | 1.0107 mL | 2.0213 mL | 5.0533 mL | |
| 20 mM | 0.1516 mL | 0.7580 mL | 1.5160 mL | 3.7899 mL | |
| 25 mM | 0.1213 mL | 0.6064 mL | 1.2128 mL | 3.0320 mL | |
| 30 mM | 0.1011 mL | 0.5053 mL | 1.0107 mL | 2.5266 mL | |
| 40 mM | 0.0758 mL | 0.3790 mL | 0.7580 mL | 1.8950 mL | |
| 50 mM | 0.0606 mL | 0.3032 mL | 0.6064 mL | 1.5160 mL | |
| 60 mM | 0.0505 mL | 0.2527 mL | 0.5053 mL | 1.2633 mL | |
| 80 mM | 0.0379 mL | 0.1895 mL | 0.3790 mL | 0.9475 mL | |
| 100 mM | 0.0303 mL | 0.1516 mL | 0.3032 mL | 0.7580 mL |
CBT-295 関連分類
HY-169004 関連分類
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