Cedazuridine
Based on 1 publication(s) in Google Scholar
Cedazuridine (E7727) (Compound 7a) is an orally active cytidine deaminase (CDA) inhibitor with an IC50 value of 0.4 μM. Cedazuridine can be used for cancer research.
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- 純度: 99.72%
- CAS 番号: 1141397-80-9
- 分子式: C9H14F2N2O5
- 分子量:268.21
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 Cedazuridine
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生物活性
IC50: 0.4 μM (CDA)[1]
Cedazuridine (Compound 7a) exhibits superior acid stability[1].
Cedazuridine (0-10 μM; 72 h) does not enhance effects of AZA (5-Azacytidine, HY-10586) in growth inhibition of AML cell lines[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female NSGS mice, 6–8 weeks old, human cell line-derived (CDX) and primary patient-derived xenograft (PDX) models[2]
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Dosage:3 mg/kg
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Administration:Oral administration, in combination with 2.5 mg/kg AZA, daily for 7 days
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Result:Led to reduction of leukemic expansion in combination with AZA in a cell line-derived xenograft transplantation, and exhibited preliminary safety and efcacy in a primary AML PDX model.
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Animal Model:NSGS male mice[2]
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Dosage:1, 3, 10 and 30 mg/kg
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Administration:Oral, in combination with 2.5 mg/kg AZA (Pharmacokinetic Studies)
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Result:Dose-dependently increased the AUC of oral AZA and in comparison to dosing of standard i.p. AZA.
化学情報
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CAS 番号 1141397-80-9
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性状 Solid
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分子量 268.21
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分子式 C9H14F2N2O5
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Color White to off-white
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SMILES
O[C@H]1C(F)(F)[C@H](N(CC[C@@H](O)N2)C2=O)O[C@@H]1CO
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別名
E7727
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Cancer Res Commun
Mechanisms Underlying Cedazuridine-Mediated Enhancement of Oral Decitabine Bioavailability. [Abstract]2026 Mar 2. PMID: 41770597
溶剤 & 溶解度
DMSO : 116.67 mg/mL (434.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (278 KB)
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SDS (557 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7284 mL | 18.6421 mL | 37.2842 mL | 93.2105 mL |
| 5 mM | 0.7457 mL | 3.7284 mL | 7.4568 mL | 18.6421 mL | |
| 10 mM | 0.3728 mL | 1.8642 mL | 3.7284 mL | 9.3211 mL | |
| 15 mM | 0.2486 mL | 1.2428 mL | 2.4856 mL | 6.2140 mL | |
| 20 mM | 0.1864 mL | 0.9321 mL | 1.8642 mL | 4.6605 mL | |
| 25 mM | 0.1491 mL | 0.7457 mL | 1.4914 mL | 3.7284 mL | |
| 30 mM | 0.1243 mL | 0.6214 mL | 1.2428 mL | 3.1070 mL | |
| 40 mM | 0.0932 mL | 0.4661 mL | 0.9321 mL | 2.3303 mL | |
| 50 mM | 0.0746 mL | 0.3728 mL | 0.7457 mL | 1.8642 mL | |
| 60 mM | 0.0621 mL | 0.3107 mL | 0.6214 mL | 1.5535 mL | |
| 80 mM | 0.0466 mL | 0.2330 mL | 0.4661 mL | 1.1651 mL | |
| 100 mM | 0.0373 mL | 0.1864 mL | 0.3728 mL | 0.9321 mL |
Cedazuridine 関連分類
HY-109081 関連分類
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