CL075
Based on 3 publication(s) in Google Scholar
CL075 (3M002) is a selective TLR8 agonist with immunomodulating properties. CL075 triggers a MyD88-dependent signaling pathway to elicit production of inflammatory cytokines and type I interferons (IFNs) via activation of NF-κB and IRF7, respectively.
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- 純度: 99.18%
- CAS 番号: 256922-53-9
- 分子式: C13H13N3S
- 分子量:243.33
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 CL075
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生物活性
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TLR8 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
1.32 μM
Compound: 40, CL075
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Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline phosphatase by HEK-blue reporter gene assay
Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline phosphatase by HEK-blue reporter gene assay
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[PMID: 22924757] |
CL075 (2 μM; 4 h) induces the production of IL-6, IL-8, and IFN-γ in rabbit splenocytes[1].
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CL075 (2 μM; 48 h) induces the total IgM production and cell proliferation in rabbit splenocytes[1].
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CL075 (2 μM; 7 h) activates the rabTLR8 in 293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 256922-53-9
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性状 Solid
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分子量 243.33
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分子式 C13H13N3S
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Color White to off-white
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SMILES
NC1=NC2=CC=CC=C2C(S3)=C1N=C3CCC
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別名
3M002
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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Neural Regen Res
Porcine decellularized nerve matrix hydrogel attenuates neuroinflammation after peripheral nerve injury by inhibiting the TLR4/MyD88/NF-κB axis. [Abstract]2026 Mar 1;21(3):1222-1235. PMID: 39589179 -
Burns
Lipopolysaccharide induces skin scarring through the TLR4/Myd88 inflammatory signaling pathway in dermal fibroblasts. [Abstract]2023 Dec;49(8):1997-2006. PMID: 37821278 -
J Biomater Appl
Stromal vascular fraction gel promoted wound healing and peripheral nerve repair in diabetic rats via TLRs/MyD88/NF-κB signaling pathway. [Abstract]2023 Jul;38(1):146-156. PMID: 37341245
溶剤 & 溶解度
DMSO : 22 mg/mL (90.41 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Lai CY, et, al. TLR7/8 agonists activate a mild immune response in rabbits through TLR8 but not TLR7. Vaccine. 2014 Sep 29;32(43):5593-9. [Content Brief]
[2]. Spranger S, et, al. Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J Immunol. 2010 Jul 1;185(1):738-47. [Content Brief]
[3]. Maalej KM, et, al. TLR8, but not TLR7, induces the priming of the NADPH oxidase activation in human neutrophils. J Leukoc Biol. 2015 Jun;97(6):1081-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.1096 mL | 20.5482 mL | 41.0965 mL | 102.7411 mL |
| 5 mM | 0.8219 mL | 4.1096 mL | 8.2193 mL | 20.5482 mL | |
| 10 mM | 0.4110 mL | 2.0548 mL | 4.1096 mL | 10.2741 mL | |
| 15 mM | 0.2740 mL | 1.3699 mL | 2.7398 mL | 6.8494 mL | |
| 20 mM | 0.2055 mL | 1.0274 mL | 2.0548 mL | 5.1371 mL | |
| 25 mM | 0.1644 mL | 0.8219 mL | 1.6439 mL | 4.1096 mL | |
| 30 mM | 0.1370 mL | 0.6849 mL | 1.3699 mL | 3.4247 mL | |
| 40 mM | 0.1027 mL | 0.5137 mL | 1.0274 mL | 2.5685 mL | |
| 50 mM | 0.0822 mL | 0.4110 mL | 0.8219 mL | 2.0548 mL | |
| 60 mM | 0.0685 mL | 0.3425 mL | 0.6849 mL | 1.7124 mL | |
| 80 mM | 0.0514 mL | 0.2569 mL | 0.5137 mL | 1.2843 mL |
CL075 関連分類
HY-117066 関連分類
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