Cryptopine
Cryptopine is a non-narcotic isoquinoline alkaloid. Cryptopine can reduce the activities of glutathione S-transferase (GST) and glutathione reductase (GR), depletes intracellular glutathione levels, stimulates lipid peroxidation, and induces cytotoxicity by disrupting the cellular defense system. Cryptopine binds stably to key targets of liver cancer and also exhibits anthelmintic activity against Dactylogyrus intermedius. Cryptopine can be used in studies related to liver cancer and Dactylogyrus intermedius infection.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 482-74-6
- 分子式: C21H23NO5
- 分子量:369.41
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Cryptopine is a bioactive component of Fumaria indica. It targets key genes and pathways associated with human liver cancer. Network analysis shows that it acts on core liver cancer genes MTOR, MAPK3, PIK3R1 and EGFR, and KEGG enrichment analysis identifies its involvement in pathways including PI3K-AKT-mTOR, MAPK, EGF, p53 and NF-κB[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Cryptopine (3-8 mg/L; 48 h) exhibits anthelmintic activity in goldfish infected with Dactylogyrus, with an EC50 of 3.31 mg/L[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar (male, 125-150 g)[2]
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Dosage:50 mg/kg; 100 mg/kg; 150 mg/kg; 200 mg/kg
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Administration:p.o.; daily; 5 days
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Result:Increased liver MDA (a lipid peroxidation product).
Reduced the activities of GSH, GST and GR in the liver, causing severe liver damage.
化学情報
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CAS 番号 482-74-6
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性状 Liquid
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分子量 369.41
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分子式 C21H23NO5
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SMILES
CN(CC1=C(C=CC2=C1OCO2)C3)CCC4=C(C3=O)C=C(OC)C(OC)=C4
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1].
Batool S, et al. Network Pharmacology and Bioinformatics Approach Reveals the Multi-Target Pharmacological Mechanism of Fumaria indica in the Treatment of Liver Cancer. Pharmaceuticals (Basel). 2022 May 25;15(6):654.
[Content Brief]
[2]. Aneja R, et al. Stimulation of lipid peroxidation and impairment of glutathione-dependent defense system in Wistar rats treated with cryptopine, a rare non-narcotic opium alkaloid. European journal of drug metabolism and pharmacokinetics. 2004;29(1):31-6. [Content Brief]
[3]. Vrancheva RZ, et al. Alkaloid profiles and acetylcholinesterase inhibitory activities of Fumaria species from Bulgaria. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2016;71(1-2):9-14. [Content Brief]
[4]. Wang GX, et al. In vivo anthelmintic activity of five alkaloids from Macleaya microcarpa (Maxim) Fedde against Dactylogyrus intermedius in Carassius auratus. Veterinary parasitology. 2010 Aug 04;171(3-4):305-13. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Cryptopine 関連分類
HY-121260 関連分類
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