D-520
D-520 is a potent and brain-penetrant dopamine D2/D3 agonist (D2 EC50 = 4.73 nM, Ki = 41.8 nM; D3 EC50 = 2.18 nM, Ki = 0.35 nM). D-520 inhibits the formation of Aβ aggregates in vitro and promotes the disaggregation of both alpha-synuclein (α-syn) and Aβ aggregates. D-520 exhibits efficacious activity in animal models of Parkinson’s disease (PD). D-520 can be used for PD and PD with dementia (PDD) research[1][2].
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1619269-47-4
- 分子式: C31H39N3O3
- 分子量:501.66
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[2]|
D2 Receptor 4.73 nM (EC50) |
D3 Receptor 2.18 nM (EC50) |
D2L Receptor 41.8 nM (Ki) |
D3 Receptor 0.35 nM (Ki) |
体外実験
D-520 (0.01-30 μM, 24 h) exhibits dose-dependent neuroprotective effects against 6-hydroxydopamine (6-OHDA) (HY-B1081)-induced toxicity in MN9D dopaminergic cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
化学情報
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CAS 番号 1619269-47-4
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分子量 501.66
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分子式 C31H39N3O3
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SMILES
OC1=CC(C2=CC=C(N3CCN(CCN(CCC)[C@@H]4CC5=C(C(O)=CC=C5)CC4)CC3)C=C2)=CC=C1O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
純度とドキュメンテーション
参考文献
[1]. Yedlapudi D, et al. Targeting alpha synuclein and amyloid beta by a multifunctional, brain-penetrant dopamine D2/D3 agonist D-520: Potential therapeutic application in Parkinson's disease with dementia. Sci Rep. 2019 Dec 23;9(1):19648. [Content Brief]
[2]. Modi G, et al. Multifunctional D2/D3 agonist D-520 with high in vivo efficacy: modulator of toxicity of alpha-synuclein aggregates. ACS Chem Neurosci. 2014 Aug 20;5(8):700-17. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
D-520 関連分類
HY-120156 関連分類
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