DNMT3A-IN-4
DNMT3A-IN-4 is a DNMT3A inhibitor with an IC50 of 33.4 μM against human DNMT3A. DNMT3A-IN-4 inhibits the proliferation of colorectal cancer cells and can be used for the research of colorectal cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C20H15N5O3
- 分子量:373.36
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
DNA Methyltransferase アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
[1]|
DNMT3A 33.4 μM (IC50) |
体外実験
DNMT3A-IN-4 (compound 6o) (100-320 μM; 1 h) preferentially inhibits recombinant human DNMT3A/3L over DNMT1, and shows only weak inhibitory activity against DNMT1 even at concentrations as high as 320 μM[1].
DNMT3A-IN-4 (25-150 μM; 24-72 h) does not reduce the viability of HCT116 colorectal cancer cells[1].
DNMT3A-IN-4 (100 μM; 24 h) does not reduce the protein abundance of DNMT1 or DNMT3A in HCT116 colorectal cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 373.36
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分子式 C20H15N5O3
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SMILES
O=C1NC2=C(C(C3=CC=C(N4C=CN=C4)C=C3)C5=C(O2)C=C(O)C=C5)C(N)=N1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
DNMT3A-IN-4 関連分類
HY-184332 関連分類
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