F3 peptide
F3 peptide is a nucleolin-binding tumor-homing peptide that mediates selective uptake and internalization by tumor cells. F3 peptide is a 31-amino acid fragment of human high mobility group nucleosomal protein 2 (HMGN2). F3 peptide inhibits protein synthesis through ribosome inactivation. F3 peptide targets the tumor vasculature. F3 peptide can serve as an effective ligand to improve the druggability of macromolecular drugs or nanoparticles. F3 peptide is used in research on cancers such as glioblastoma and breast cancer.
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- CAS 番号: 536971-53-6
- 分子式: C152H263N49O41
- 分子量:3433.02
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
体外実験
FITC-F3 peptide (10 nM; 2 h) binds to the 231-H2N cell membrane, internalizes, and translocates to the nucleus and nucleolus, colocalizing with nucleolin[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:MDA-MB-231-H2N (231-H2N) human breast cancer cells
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Concentration:10 nM
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Incubation Time:2 h
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Result:Showed membrane-bound and internalized fluorescence.
Observed in the nuclei, where it co-localized with nucleolin in the nucleoli.
Nuclear localization was approximately 33.6% of the total amount internalized.
化学情報
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CAS 番号 536971-53-6
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分子量 3433.02
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分子式 C152H263N49O41
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配列
Lys-Asp-Glu-Pro-Gln-Arg-Arg-Ser-Ala-Arg-Leu-Ser-Ala-Lys-Pro-Ala-Pro-Pro-Lys-Pro-Glu-Pro-Lys-Pro-Lys-Lys-Ala-Pro-Ala-Lys-Lys
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シーケンスの短縮
KDEPQRRSARLSAKPAPPKPEPKPKKAPAKK
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Breast Cancer Modeling
Breast cancer is a heterogeneous cancer, and it has been distinguished into four subtypes: luminal A, luminal B, HER2-positive and basal-like. Molecular mutations, epigenetic alterations, hormone exposure and immune microenvironment are related to the progression of breast cancer.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)