FC-11
Based on 1 Customer Validation
FC-11 is a PROTAC FAK degrader (DC90: 1 nM) . FC-11 contains CRBN ligand Pomalidomide (HY-10984), linker and FAK ligand PF562271 (HY-10459).
(Pink: FAK Target protein ligand; Blue: Cereblon ligand (HY-10984); Black: linker).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.95%
- CAS 番号: 2271035-37-9
- 分子式: C41H42F3N13O9S
- 分子量:949.91
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保管条件:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
PROTACs アイソフォーム固有の製品をすべて表示
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生物活性
FC-11 degrades FAK in various cell types, with DC50s being: 310 pM in TM3, 80 pM in PA1, 330 pM in MDA-MB-436, 370 pM in LNCaP, and 40 pM in Ramos[1].
FC-11 (1-10 nM, 8 h) degrades FAK in PA1 cells (compared to DMSO protein degradation) by 99%[1].
FC-11 (1-100 nM, 8 h) induces FAK degradation in PA1 through a CRBN-mediated and proteasome-dependent mechanism[1].
FC-11 (1-3000 nM, 0-9 h) inhibits FAK autophosphorylation in TM3 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2271035-37-9
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性状 Solid
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分子量 949.91
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分子式 C41H42F3N13O9S
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Color Light yellow to yellow
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SMILES
O=C(C1=CN(CCOCCOCCNC2=CC=CC(C(N3C4C(NC(CC4)=O)=O)=O)=C2C3=O)N=N1)NC5=CC=C(NC6=NC=C(C(F)(F)F)C(NCC7=CC=CN=C7N(S(=O)(C)=O)C)=N6)C=C5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶剤 & 溶解度
DMSO : 66.67 mg/mL (70.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Gao H, et al. Design, Synthesis, and Evaluation of Highly Potent FAK-Targeting PROTACs. ACS Med Chem Lett. 2019 Oct 22;11(10):1855-1862. Gao H, Wu Y, Sun Y, Yang Y, Zhou G, Rao Y. Design, Synthesis, and Evaluation of Highly Potent FAK-Targeting PROTACs. ACS Med Chem Lett. 2019 Oct 22;11(10):1855-1862. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0527 mL | 5.2637 mL | 10.5273 mL | 26.3183 mL |
| 5 mM | 0.2105 mL | 1.0527 mL | 2.1055 mL | 5.2637 mL | |
| 10 mM | 0.1053 mL | 0.5264 mL | 1.0527 mL | 2.6318 mL | |
| 15 mM | 0.0702 mL | 0.3509 mL | 0.7018 mL | 1.7546 mL | |
| 20 mM | 0.0526 mL | 0.2632 mL | 0.5264 mL | 1.3159 mL | |
| 25 mM | 0.0421 mL | 0.2105 mL | 0.4211 mL | 1.0527 mL | |
| 30 mM | 0.0351 mL | 0.1755 mL | 0.3509 mL | 0.8773 mL | |
| 40 mM | 0.0263 mL | 0.1316 mL | 0.2632 mL | 0.6580 mL | |
| 50 mM | 0.0211 mL | 0.1053 mL | 0.2105 mL | 0.5264 mL | |
| 60 mM | 0.0175 mL | 0.0877 mL | 0.1755 mL | 0.4386 mL |
FC-11 関連分類
HY-139344 関連分類
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