Ferroheme
Based on 1 publication(s) in Google Scholar
Ferroheme is the ferrous form of heme in hemoglobin, reversibly binding oxygen as an oxygen carrier. Its free form induces oxidative stress and ferroptosis by releasing iron ions, which catalyze reactive oxygen species generation via Fenton reactions, leading to lipid peroxidation and cell death. This mechanism is critical in pathological contexts like intracerebral hemorrhage and neurodegenerative diseases, making it a target for studying iron-overload disorders and ferroptosis-related pathologies[1][2][3].
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- 純度 : 99.70%
- CAS 番号: 14875-96-8
- 分子式: C34H32FeN4O4
- 分子量:616.49
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保管条件:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Help & FAQs
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HY-19424
HeminHeme Oxygenase-1 Inducer -
HY-137808
Succinyl-Coenzyme A sodiumCoenzyme A Derivative -
HY-B0511
BiotinVitamin B7 -
HY-W355129
MeIQxDietary Aromatic Amine -
HY-B0399
L-CarnitineCo-factor for β-oxidation -
HY-N0323
BilirubinAntioxidant -
HY-B1342
Vitamin A -
HY-B1247
Protoporphyrin IXEndogenous Metabolite,Cancer Inhibitor -
HY-12364
C75Fatty Acid Synthase Inhibitor -
HY-14452
FatostatinSREBP Activation Inhibitor -
HY-112829
DenifanstatFASN Inhibitor -
HY-108915
Trimethylamine N-oxide dihydrateROS/NLRP3 Inflammasome Activator
MedChemExpress（MCE）の使用を引用している文献 Ferroheme
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生物活性
製品説明
体外実験
Ferroheme (5 μM; 24 h) significantly reduces neuronal viability and induces ferroptosis-related lipid peroxidation[1]. Ferroheme (10 μM; 48 h) promotes glioma cell ferroptosis via upregulation of ACSL4 and LPCAT3, accompanied by decreased GPX4 expression[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 14875-96-8
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性状 Solid
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分子量 616.49
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分子式 C34H32FeN4O4
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Color Brown to black
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SMILES
[O-]C(CCC(C1=CC(C(CCC([O-])=O)=C2C)=[N](C2=C3)[Fe+2]4([N-]5C3=C6C)[N-]1C7=CC(C(C=C)=C8C)=[N]4C8=CC5=C6C=C)=C7C)=O.[H+].[H+]
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Immunol
TLR4al senses heme as a key damage/danger-associated molecular pattern to activate immune responses in lower vertebrates. [Abstract]2025 Aug 19:vkaf192. PMID: 40829171
溶剤 & 溶解度
体外:
1 M NaOH : 50 mg/mL (81.10 mM; Need ultrasonic)
H2O : 10 mg/mL (16.22 mM; ultrasonic and adjust pH to 10 with 1M NaOH)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (281 KB)
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SDS (393 KB)
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- Italian - IT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. J M Stewart, et al. Ferriheme and ferroheme are isosteric inhibitors of fatty acid binding to rat liver fatty acid binding protein. Biochem Cell Biol. 1996;74(2):249-55. [Content Brief]
[2]. L Pauling, et al. The Magnetic Properties and Structure of Hemoglobin, Oxyhemoglobin and Carbonmonoxyhemoglobin. Proc Natl Acad Sci U S A. 1936 Apr;22(4):210-6. [Content Brief]
[3]. Derry P J, et al. The chemical basis of intracerebral hemorrhage and cell toxicity with contributions from eryptosis and ferroptosis. Frontiers in Cellular Neuroscience, 2020, 14: 603043. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / 1 M NaOH | 1 mM | 1.6221 mL | 8.1104 mL | 16.2209 mL | 40.5522 mL |
| 5 mM | 0.3244 mL | 1.6221 mL | 3.2442 mL | 8.1104 mL | |
| 10 mM | 0.1622 mL | 0.8110 mL | 1.6221 mL | 4.0552 mL | |
| 15 mM | 0.1081 mL | 0.5407 mL | 1.0814 mL | 2.7035 mL | |
| 1 M NaOH | 20 mM | 0.0811 mL | 0.4055 mL | 0.8110 mL | 2.0276 mL |
| 25 mM | 0.0649 mL | 0.3244 mL | 0.6488 mL | 1.6221 mL | |
| 30 mM | 0.0541 mL | 0.2703 mL | 0.5407 mL | 1.3517 mL | |
| 40 mM | 0.0406 mL | 0.2028 mL | 0.4055 mL | 1.0138 mL | |
| 50 mM | 0.0324 mL | 0.1622 mL | 0.3244 mL | 0.8110 mL | |
| 60 mM | 0.0270 mL | 0.1352 mL | 0.2703 mL | 0.6759 mL | |
| 80 mM | 0.0203 mL | 0.1014 mL | 0.2028 mL | 0.5069 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Ferroheme 関連分類
HY-111914A 関連分類
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