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製品番号: HY-150791

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FLDP-5

FLDP-5 is a blood-brain barrier (BBB) penetrant curcuminoid analogues. FLDP-5 can induce production of ROS (Reactive Oxygen Species), DNA damage and cell cycle S phase arrest. FLDP-5 exhibits highly potent tumour-suppressive effects with anti-proliferative and anti-migratory activities on LN-18 cells.

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CAS 番号: 950665-12-0
分子式: C₂₁H₂₁NO₅
分子量:367.40

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

FLDP-5 構造式

CAS 番号: 950665-12-0

容量

価格（税別）

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Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
C6	IC₅₀	3.9 μM Compound: 14	Antiproliferative activity against rat C6 cells after 72 hrs by MTT assay Antiproliferative activity against rat C6 cells after 72 hrs by MTT assay	[PMID: 20831222]
Caco-2	IC₅₀	0.2 μM Compound: 14	Antiproliferative activity against human Caco-2 cells after 72 hrs by MTT assay Antiproliferative activity against human Caco-2 cells after 72 hrs by MTT assay	[PMID: 20831222]
HaCaT	IC₅₀	3 μM Compound: 14	Antiproliferative activity against human HaCaT cells after 72 hrs by MTT assay Antiproliferative activity against human HaCaT cells after 72 hrs by MTT assay	[PMID: 20831222]
HT-22	IC₅₀	3.1 μM Compound: 14	Antiproliferative activity against mouse HT22 cells after 72 hrs by MTT assay Antiproliferative activity against mouse HT22 cells after 72 hrs by MTT assay	[PMID: 20831222]
NB-4	IC₅₀	0.4 μM Compound: 231	Cytotoxicity against human NB4 cells assessed as reduction in cell viability after 72 hrs by MTS assay Cytotoxicity against human NB4 cells assessed as reduction in cell viability after 72 hrs by MTS assay	[PMID: 24960549]
NIH3T3	IC₅₀	4.2 μM Compound: 14	Antiproliferative activity against BALB/c mouse 3T3 cells after 72 hrs by MTT assay Antiproliferative activity against BALB/c mouse 3T3 cells after 72 hrs by MTT assay	[PMID: 20831222]
SH-SY5Y	IC₅₀	2.1 μM Compound: 14	Antiproliferative activity against human SH-SY5Y cells after 72 hrs by MTT assay Antiproliferative activity against human SH-SY5Y cells after 72 hrs by MTT assay	[PMID: 20831222]

体外実験

FLDP-5 (0-20 μM; 24 h) has cytotoxicity on human glioblastoma multiforme (GBM) LN-18 cells and HBEC-5i^[1].
FLDP-5 (2.5 μM; 0-6 h) induces superoxide and hydrogen peroxide in LN-18 cell death^[1].
FLDP-5 (2.5 μM; 0-4 h) induces DNA damage with a time-dependent manner in LN-18 cells^[1].
FLDP-5 (1.25 and 2.5 μM; 24 and 48 h) potentiates anti-migration effects in LN-18 cells^[1].
FLDP-5 (1.25 and 2.5 μM; 24 h) reduces the percentage of relative invasion in LN-18 cells in a significant dose-dependent manner^[1].
FLDP-5 (0.625 and 1.25 μM; 24 h) induces arrest in S phase in a concentration-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

LN-18 and HBEC-5i cells
Concentration:

0-20 μM
Incubation Time:

24 h
Result:

Exhibited cytotoxicity on human GBM LN-18 cells and HBEC-5i with IC₅₀s of 2.4 μM and 5.6 μM.

Cell Migration Assay ^[1]

Cell Line:

LN-18 cells
Concentration:

1.25 and 2.5 μM
Incubation Time:

24 and 48 h
Result:

Potentiated anti-migration effects in LN-18 cells with wound closure of 56.43% ± 6.28 and 3.17% ± 0.71 at 1.25 μM and 2.5 μM (48 h), respectively.

Cell Invasion Assay^[1]

Cell Line:

LN-18 cells
Concentration:

1.25 and 2.5 μM
Incubation Time:

24 h
Result:

Reduced the percentage of relative invasion in LN-18 cells in a significant dose-dependent manner.

Cell Cycle Analysis^[1]

Cell Line:

LN-18 cells
Concentration:

0.625 and 1.25 μM
Incubation Time:

24 h
Result:

Induced arrest in S phase in a concentration-dependent manner, and exhibited accumulation of 63.38% ± 4.42 at 1.25 μM.

化学情報

CAS 番号 950665-12-0
分子量 367.40
分子式 C₂₁H₂₁NO₅
SMILES

O=C1/C(CNC/C1=C\C2=CC=C(O)C(OC)=C2)=C/C3=CC=C(O)C(OC)=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Razali NSC, et al. Curcumin piperidone derivatives induce anti-proliferative and anti-migratory effects in LN-18 human glioblastoma cells. Sci Rep. 2022 Jul 30;12(1):13131. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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生物活性
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- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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FLDP-5

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

FLDP-5 関連分類

HY-150791 関連分類