Fumarranol
Fumarranol, a Fumagillin (HY-B0751) analogue, is a selective type 2 methionine aminopeptidase (MetAP2) inhibitor with a human IC50 of 3.2 μM. Fumarranol inhibits proliferation of bovine aortic endothelial cells and inhibits angiogenesis in a mouse matrigel plug model. Fumarranol can be used for the researches of cancer, diabetic retinopathy, age-related macular degeneration.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 912569-37-0
- 分子式: C16H24O4
- 分子量:280.36
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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生物活性
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MetAp2 3.2 μM (IC50) |
Fumarranol (0-100 μM) selectively inhibits recombinant hMetAP2 enzymatic activity with an IC50 of 3.2 μM, and does not inhibit hMetAP1 at 100 μM[1].
Fumarranol inhibits bovine aortic endothelial cell proliferation with an IC50 of 34 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 912569-37-0
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分子量 280.36
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分子式 C16H24O4
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SMILES
O(C)[C@]12[C@](CO)([C@]1([C@]3(C)[C@@H](CC=C(C)C)O3)[H])CCC2=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Fumarranol 関連分類
HY-133806 関連分類
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