GA-017
Based on 7 publication(s) in Google Scholar
GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.95%
- CAS 番号: 2351906-74-4
- 分子式: C18H21N3O4
- 分子量:343.38
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 GA-017
More- Mol Cell. 2024 Aug 18:S1097-2765(24)00633-6. [Abstract]
- Cell Rep Med. 2026 Feb 17;7(2):102622. [Abstract]
- Cell Death Dis. 2026 Mar 26;17(1):381. [Abstract]
- Int Immunopharmacol. 2026 Jan 1;168(Pt 1):115828. [Abstract]
- Cancer Biother Radiopharm. 2025 Mar;40(2):139-150 [Abstract]
- bioRxiv. 2025 April 14.
- SSRN. 2025 Jan 3.
Customer Validation & Images
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RT-PCR
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Cell Migration/Invasion Assay
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Cell Migration/Invasion Assay
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RT-PCR
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WB
YAP アイソフォーム固有の製品をすべて表示
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生物活性
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Lats1 |
Lats2 |
YAP/TAZ |
GA-017 suppresses the cell death of HUVECs and promotes their cell growth[1].
GA-017 facilitates SKOV3 cell growth, with an EC50 of 3.51 ± 0.26 μM[1].
GA-017 competitively inhibited LATS1 and 2 against ATP, with Ki (inhibition constant) values of 0.58 ± 0.11 and 0.25 ± 0.03 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2351906-74-4
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性状 Solid
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分子量 343.38
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分子式 C18H21N3O4
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Color Off-white to light yellow
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SMILES
O=C(NCC1=CC(O)=CC=C1)N/N=C(CC)\C2=CC=C(C(C)=C2O)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (7)
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Journal Impact Factor
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Most Recent
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Mol Cell
Consecutive palmitoylation and phosphorylation orchestrates NLRP3 membrane trafficking and inflammasome activation. [Abstract]2024 Aug 18:S1097-2765(24)00633-6. PMID: 39173637
GA-017 purchased from MedChemExpress. Usage Cited in: Mol Cell. 2024 Aug 18:S1097-2765(24)00633-6. [Abstract]
Caspase-1 (p20) and gasdermin D (cleaved N-term) processing upon NLRP3 inflammasome in BMDM cells with or without the treatment of TRULI and GA-017 (10 μM, 5h) .
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Cell Rep Med
A human patient-derived organoid biobank to model tumor heterogeneity and therapeutic vulnerability for oral squamous cell carcinoma. [Abstract]2026 Feb 17;7(2):102622. PMID: 41707653 -
Cell Death Dis
Generation of proliferative hESC-derived grape-clustered hepatocyte organoids with multipolar architecture as regenerative counterpart via synergy of YAP and IGF2 pathways. [Abstract]2026 Mar 26;17(1):381. PMID: 41888105 -
Int Immunopharmacol
ACTL6A accelerates the progression of NSCLC through hippo/YAP signaling axis and TAMs-mediated immune regulation. [Abstract]2026 Jan 1;168(Pt 1):115828. PMID: 41223612
GA-017 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Jan 1;168(Pt 1):115828. [Abstract]
ACTL6A-interfered NCI-H520 cells were treated with GA-017 (10 μM) and K-975 for 24 h. Then, qRT-PCR was used to detect the expression of TEAD1 and TEAD4.
GA-017 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Jan 1;168(Pt 1):115828. [Abstract]
GA-017 (10 μM) for 24 h. Wound healing assay (scale bar =100 μm) was performed to detect the changes of NCI-H520 cell migration. *P < 0.05, **P < 0.01 and ***P < 0.001.
GA-017 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Jan 1;168(Pt 1):115828. [Abstract]
GA-017 (10 μM) for 24 h. Transwell assay (scale bar =50 μm) was performed to detect the changes of cell migration. *P < 0.05, **P < 0.01 and ***P < 0.001.
GA-017 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Jan 1;168(Pt 1):115828. [Abstract]
ACTL6A-interfered NCI-H520 cells were treated with GA-017 (10 μM) for 24 h or K-975. Then, qRT-PCR was performed to detect the expression of CSF1.
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Cancer Biother Radiopharm
Dihydroartemisinin Inhibits Epithelial-Mesenchymal Transition Progression in Medullary Thyroid Carcinoma Through the Hippo Signaling Pathway Regulated by Interleukin-6. [Abstract]2025 Mar;40(2):139-150 PMID: 39286872 -
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溶剤 & 溶解度
DMSO : 20.83 mg/mL (60.66 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9122 mL | 14.5611 mL | 29.1223 mL | 72.8056 mL |
| 5 mM | 0.5824 mL | 2.9122 mL | 5.8245 mL | 14.5611 mL | |
| 10 mM | 0.2912 mL | 1.4561 mL | 2.9122 mL | 7.2806 mL | |
| 15 mM | 0.1941 mL | 0.9707 mL | 1.9415 mL | 4.8537 mL | |
| 20 mM | 0.1456 mL | 0.7281 mL | 1.4561 mL | 3.6403 mL | |
| 25 mM | 0.1165 mL | 0.5824 mL | 1.1649 mL | 2.9122 mL | |
| 30 mM | 0.0971 mL | 0.4854 mL | 0.9707 mL | 2.4269 mL | |
| 40 mM | 0.0728 mL | 0.3640 mL | 0.7281 mL | 1.8201 mL | |
| 50 mM | 0.0582 mL | 0.2912 mL | 0.5824 mL | 1.4561 mL | |
| 60 mM | 0.0485 mL | 0.2427 mL | 0.4854 mL | 1.2134 mL |
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