Gemlapodect
Gemlapodect (RO554965) is an inhibitor of phosphodiesterase 10A (PDE10A). Gemlapodect can be used for researching schizophrenia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1380329-87-2
- 分子式: C22H21N7O3
- 分子量:431.45
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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PDE10A |
Gemlapodect (10 mg/kg; p.o.; single dose) shows nothing change in glucose tolerance of 9 weeks male SD rats[2].
Gemlapodect (0.3 mg/kg; p.o.; once daily for 8 days) induces a slight glucose tolerance improvement, no changes in fasting blood glucose, and decreases of fasting insulin in 10 weeks male SD rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male patients with COFD (18-50 years old)[2].
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Dosage:5-15 mg.
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Administration:Oral gavage; once daily for 6 weeks.
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Result:Improved the Stuttering, work, social life, family life and home responsibilities of COFD patients and showed biosafety.
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Animal Model:9 weeks or 10 weeks male SD rats[2].
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Dosage:0.3 mg/kg or 10 mg/kg.
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Administration:Oral gavage; once daily for 1 or 8 days.
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Result:Showed insignificantly change of glucose tolerance in healthy rats.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 1380329-87-2
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分子量 431.45
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分子式 C22H21N7O3
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SMILES
O=C(C1=C(C(N2CCOCC2)=O)C=NN1C)NC3=CC4=NC(C5=CC=CC=C5)=NN4C=C3
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別名
RO554965
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Gemlapodect 関連分類
HY-152838 関連分類
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