MAD2L2 - mitotic arrest deficient 2 like 2 Gene

Also Known as REV7; FANCV; MAD2B; POLZ2

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 10459

About MAD2L2

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:11,674,480-11,691,830 (from NCBI)

This gene has 12 transcripts (splice variants), 202 orthologues, 1 paralogue and is associated with 2 phenotypes. Broad expression in testis (RPKM 22.7), bone marrow (RPKM 15.4) and 25 other tissues.

Summary

The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins. [provided by RefSeq, Jul 2008]

MAD2L2 Products (2)

mRNA	Protein	Name
NM_001127325.2	NP_001120797.1	mitotic spindle assembly checkpoint protein MAD2B
NM_006341.4	NP_006332.3	mitotic spindle assembly checkpoint protein MAD2B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables JUN kinase binding	IDA IDA: Inferred from direct assay	17296730	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	19443654	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10527948	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in DNA damage response, signal transduction resulting in transcription	IDA IDA: Inferred from direct assay	17296730	GOA
involved in actin filament organization	IMP IMP: Inferred from mutant phenotype	19443654	GOA
involved in double-strand break repair	IGI IGI: Inferred from genetic interaction	15988022	GOA
involved in error-prone translesion synthesis	IDA IDA: Inferred from direct assay	24449906	GOA
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	19443654	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	19443654	GOA
involved in negative regulation of cell-cell adhesion mediated by cadherin	IMP IMP: Inferred from mutant phenotype	19443654	GOA
involved in negative regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	29656893	GOA
involved in negative regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	19443654	GOA
involved in negative regulation of protein catabolic process	IDA IDA: Inferred from direct assay	11459826	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19443654	GOA
involved in negative regulation of transcription by competitive promoter binding	IMP IMP: Inferred from mutant phenotype	19443654	GOA
involved in negative regulation of transcription regulatory region DNA binding	IMP IMP: Inferred from mutant phenotype	19443654	GOA
involved in negative regulation of ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	11459826	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17296730	GOA
involved in positive regulation of double-strand break repair via nonhomologous end joining	IDA IDA: Inferred from direct assay	29656893	GOA
involved in positive regulation of isotype switching	IDA IDA: Inferred from direct assay	29656893	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	17296730	GOA
involved in regulation of cell growth	IGI IGI: Inferred from genetic interaction	15988022	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
part of anaphase-promoting complex	IDA IDA: Inferred from direct assay	11459825	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17541814	GOA
located in spindle	IDA IDA: Inferred from direct assay	21063390	GOA
part of zeta DNA polymerase complex	IDA IDA: Inferred from direct assay	20164194	GOA
part of zeta DNA polymerase complex	IPI IPI: Inferred from physical interaction	24449906	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAD2L2 Protein Structure

HORMA

0
100
200
211 a.a.

Protein Preferred Names	Protein Names
mitotic spindle assembly checkpoint protein MAD2B	MAD2 (mitotic arrest deficient, yeast, homolog)-like 2

MAD2L2 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	MAD2L2	Q9UI95	ZNF511	Homo sapiens	Q8NB15	Y2H Prey Pooling	32296183
Intra	MAD2L2	Q9UI95	ZNF511	Homo sapiens	Q8NB15	Y2H Array	32296183
Intra	MAD2L2	Q9UI95	SFI1	Homo sapiens	A8K8P3-4	Y2H Prey Pooling	25416956
Intra	MAD2L2	Q9UI95	SFI1	Homo sapiens	A8K8P3-4	Y2H Array	25416956
Intra	MAD2L2	Q9UI95	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	MAD2L2	Q9UI95	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	MAD2L2	Q9UI95	CAMK2B	Homo sapiens	Q13554	Validated Y2H	25416956
Intra	MAD2L2	Q9UI95	CAMK2B	Homo sapiens	Q13554	Y2H Array	25416956
Intra	MAD2L2	Q9UI95	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	MAD2L2	Q9UI95	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	MAD2L2	Q9UI95	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	MAD2L2	Q9UI95	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	MAD2L2	Q9UI95	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	MAD2L2	Q9UI95	ZMYND12	Homo sapiens	Q9H0C1	Y2H Array	32296183
Intra	MAD2L2	Q9UI95	ZMYND12	Homo sapiens	Q9H0C1	Y2H Prey Pooling	32296183
Intra	MAD2L2	Q9UI95	CIMIP1	Homo sapiens	Q9H1P6	Y2H Prey Pooling	32296183
Intra	MAD2L2	Q9UI95	CIMIP1	Homo sapiens	Q9H1P6	Y2H Array	32296183
Intra	MAD2L2	Q9UI95	DEPDC5	Homo sapiens	O75140-2	Y2H Array	32296183
Intra	MAD2L2	Q9UI95	DEPDC5	Homo sapiens	O75140-2	Y2H Prey Pooling	32296183
Intra	MAD2L2	Q9UI95	MBD3L1	Homo sapiens	Q8WWY6	Y2H Array	32296183
Intra	MAD2L2	Q9UI95	MBD3L1	Homo sapiens	Q8WWY6	Y2H Prey Pooling	32296183
Intra	MAD2L2	Q9UI95	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	MAD2L2	Q9UI95	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183
Intra	MAD2L2	Q9UI95	PRR5L	Homo sapiens	Q6MZQ0	Y2H Array	32296183
Intra	MAD2L2	Q9UI95	PRR5L	Homo sapiens	Q6MZQ0	Y2H Prey Pooling	32296183
Intra	MAD2L2	Q9UI95	PPM1B	Homo sapiens	O75688-3	Y2H Prey Pooling	32296183
Intra	MAD2L2	Q9UI95	PPM1B	Homo sapiens	O75688-3	Y2H Array	32296183
Intra	MAD2L2	Q9UI95	FTO	Homo sapiens	Q9C0B1-2	Y2H Prey Pooling	32296183
Intra	MAD2L2	Q9UI95	FTO	Homo sapiens	Q9C0B1-2	Y2H Array	32296183
Intra	MAD2L2	Q9UI95	FAM217B	Homo sapiens	Q9NTX9	Y2H Array	32296183
Intra	MAD2L2	Q9UI95	FAM217B	Homo sapiens	Q9NTX9	Y2H Prey Pooling	32296183
Intra	MAD2L2	Q9UI95	GSC2	Homo sapiens	O15499	Y2H Prey Pooling	32296183
Intra	MAD2L2	Q9UI95	GSC2	Homo sapiens	O15499	Y2H Array	32296183
Intra	MAD2L2	Q9UI95	SHLD3	Homo sapiens	Q6ZNX1	Anti Tag CoIP	29656893
Intra	MAD2L2	Q9UI95	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	MAD2L2	Q9UI95	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	MAD2L2	Q9UI95	CHAMP1	Homo sapiens	Q96JM3	Anti Tag CoIP	29789392
Intra	MAD2L2	Q9UI95	CHAMP1	Homo sapiens	Q96JM3	Anti Tag CoIP	29656893
Intra	MAD2L2	Q9UI95	CHAMP1	Homo sapiens	Q96JM3	Anti Tag CoIP	21063390
Intra	MAD2L2	Q9UI95	CHAMP1	Homo sapiens	Q96JM3	Anti Tag CoIP	26496610
Intra	MAD2L2	Q9UI95	TRIM7	Homo sapiens	Q9C029	Y2H Array	32296183
Intra	MAD2L2	Q9UI95	TRIM7	Homo sapiens	Q9C029	Y2H Prey Pooling	32296183
Intra	MAD2L2	Q9UI95	REV3L	Homo sapiens	O60673	NMR	22828282
Intra	MAD2L2	Q9UI95	REV3L	Homo sapiens	O60673	ITC	22828282
Intra	MAD2L2	Q9UI95	REV3L	Homo sapiens	O60673	GMS	22828282
Intra	MAD2L2	Q9UI95	PLAGL2	Homo sapiens	Q9UPG8	Validated Y2H	32296183
Intra	MAD2L2	Q9UI95	PLAGL2	Homo sapiens	Q9UPG8	Y2H Array	32296183
Intra	MAD2L2	Q9UI95	PLAGL2	Homo sapiens	Q9UPG8	Y2H Prey Pooling	32296183
Intra	MAD2L2	Q9UI95	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	MAD2L2	Q9UI95	REL	Homo sapiens	Q04864	Y2H Array	25416956
Intra	MAD2L2	Q9UI95	CDC20	Homo sapiens	Q12834	Pull Down	17719540
Intra	MAD2L2	Q9UI95	CDC20	Homo sapiens	Q12834	Anti Tag CoIP	17719540
Intra	MAD2L2	Q9UI95	ZNF558	Homo sapiens	Q96NG5	Y2H Prey Pooling	32296183
Intra	MAD2L2	Q9UI95	ZNF558	Homo sapiens	Q96NG5	Y2H Array	32296183
Intra	MAD2L2	Q9UI95	THAP6	Homo sapiens	Q8TBB0	Y2H Prey Pooling	32296183
Intra	MAD2L2	Q9UI95	THAP6	Homo sapiens	Q8TBB0	Y2H Array	32296183
Intra	MAD2L2	Q9UI95	KCTD9	Homo sapiens	Q7L273	Validated Y2H	25416956
Cross	MAD2L2	Q9UI95	sctE	Shigella flexneri	P18011	Y2H	17719540
Cross	MAD2L2	Q9UI95	sctE	Shigella flexneri	P18011	Anti Tag CoIP	17719540
Cross	MAD2L2	Q9UI95	sctE	Shigella flexneri	P18011	IF	17719540
Cross	MAD2L2	Q9UI95	sctE	Shigella flexneri	P18011	Pull Down	17719540
Intra	MAD2L2	Q9UI95	TCF4	Homo sapiens	P15884	Validated Y2H	25416956
Intra	MAD2L2	Q9UI95	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	MAD2L2	Q9UI95	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	MAD2L2	Q9UI95	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	MAD2L2	Q9UI95	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	MAD2L2	Q9UI95	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	MAD2L2	Q9UI95	FZR1	Homo sapiens	Q9UM11	Anti Tag CoIP	17719540
Intra	MAD2L2	Q9UI95	ZBED1	Homo sapiens	O96006	Y2H Array	32296183
Intra	MAD2L2	Q9UI95	ZBED1	Homo sapiens	O96006	Y2H Prey Pooling	32296183
Intra	MAD2L2	Q9UI95	IKZF1	Homo sapiens	Q13422	Validated Y2H	25416956
Intra	MAD2L2	Q9UI95	IKZF1	Homo sapiens	Q13422	Y2H Prey Pooling	25416956
Intra	MAD2L2	Q9UI95	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	32296183
Intra	MAD2L2	Q9UI95	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	32296183
Intra	MAD2L2	Q9UI95	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	32296183
Intra	MAD2L2	Q9UI95	ADAM9	Homo sapiens	Q13443	Pull Down	10527948
Intra	MAD2L2	Q9UI95	ADAM9	Homo sapiens	Q13443	Y2H	10531379
Intra	MAD2L2	Q9UI95	ADAM9	Homo sapiens	Q13443	Y2H	10527948
Intra	MAD2L2	Q9UI95	RAB11FIP4	Homo sapiens	Q86YS3	Y2H Prey Pooling	32296183
Intra	MAD2L2	Q9UI95	RAB11FIP4	Homo sapiens	Q86YS3	Y2H Array	32296183
Intra	MAD2L2	Q9UI95	CDC27	Homo sapiens	P30260	Anti Bait CoIP	17719540

Cross: Cross-species interaction Intra: Intraspecies interaction

MAD2L2 抗体

製品番号	製品名	アプリケーション	反応性
HY-P83445	MAD2L2 Antibody (YA3190)	WB, ICC/IF, IP	Human
HY-P83445A	MAD2L2 Antibody (YA3190)(PBS only)	WB, ICC/IF, IP	Human

Diseases	Alias
Fanconi Anemia, Complementation Group V	Fanconi Anemia Complementation Group V FANCV
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS07951	MAD2L2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19788	Mad2l2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26284	Mad2l2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	MAD2L2	MGD	MGI:1919140
Rattus norvegicus	MAD2L2	RGD	RGD:1307499
Macaca mulatta	MAD2L2	VGNC	VGNC:74472
Felis catus	MAD2L2	VGNC	VGNC:68126
Bos taurus	MAD2L2	VGNC	VGNC:31132
Canis familiaris	MAD2L2	VGNC	VGNC:52216
Others	MAD2L2	NCBI