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製品番号: HY-184499

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GRWD5769

GRWD5769 is an orally potent ERAP1 inhibitor. GRWD5769 regulates the peptide repertoire presented by MHC-I, alters TCR diversity/clonality, reprograms antigen-experienced T cells, induces novel T cell responses, drives tumor cell killing, and alleviates T cell exhaustion. GRWD5769 can be used in the research of advanced solid malignancies, microsatellite-stable colorectal cancer, non-small cell lung cancer, bladder cancer, hepatocellular carcinoma, head and neck squamous cell carcinoma, and cervical cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2420554-24-9
分子式: C₂₂H₂₂ClN₃O₄S
分子量:459.95

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

GRWD5769 構造式

CAS 番号: 2420554-24-9

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

MHC I

ERAP1

MHC アイソフォーム固有の製品をすべて表示 :

MHC I
MHC II

Aminopeptidase アイソフォーム固有の製品をすべて表示 :

CD13
LTA4H

体外実験

Combination treatment with GRWD5769 and anti-PD-1 mAb (HY-P99144) increases intratumoral TCR repertoire diversity, promotes T cell infiltration, upregulates markers associated with immune responses as well as recently activated, non-exhausted T cells, and inhibits tumor growth across multiple syngeneic tumor models in different mouse strains.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2420554-24-9
分子量 459.95
分子式 C₂₂H₂₂ClN₃O₄S
SMILES

ClC(C=C1N2CCCCC2)=C(C#N)C=C1NS(C3=CC(C(O)=O)=CC=C3C4CC4)(=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Lillie T, et al. EMITT-1: Proof-of-mechanism immunopeptidome effects at target PK exposure, in a phase 1 study of GRWD5769 in patients with solid malignancies. ASCO Poster Session 2589. 2024.

[2]. Thistlethwaite F, et al. EMITT-1: Clinical and pharmacodynamic activity with the oral ERAP1 inhibitor GRWD5769 and cemiplimab in 6 completed phase 1b expansion cohorts in solid tumors with anti-PD-1 resistance or MSS-CRC. ASCO Oral Abstract Session 2500. 2026.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

お問い合わせ

Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
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製品名:
CAS 番号:
生物種:
純度:
数量:

GRWD5769

MHC アイソフォーム固有の製品をすべて表示

Aminopeptidase アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

GRWD5769 関連分類

HY-184499 関連分類