製品番号: HY-109178

Ifidancitinib

(別名: ATI-50002; ATI-502)

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Ifidancitinib (ATI-50002) is an orally available, potent and selective inhibitor of JAK kinase 1/3 that disrupts γc cytokine signaling. Ifidancitinib is used in the research of allergy, asthma, and autoimmune diseases.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 98.01%
CAS 番号: 1236667-40-5
分子式: C₂₀H₁₈FN₅O₃
分子量:395.39

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Ifidancitinib 構造式

CAS 番号: 1236667-40-5

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

JAK アイソフォーム固有の製品をすべて表示 :

体外実験

Ifidancitinib (0-1000 nM, 1 h) inhibits the JAK1/3 signaling pathway in mouse T cells^[2].
Ifidancitinib (0-1000 nM, 5 days) reduces the number of T cells and inhibits cell proliferation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:

T cell
Concentration:

0, 100, 300, 1000 nM
Incubation Time:

1 h
Result:

Inhibited IL-2-stimulated STAT5 phosphorylation, inhibited IFN-γ signaling, and inhibited STAT1 phosphorylation.

Cell Viability Assay^[2]

Cell Line:

T cell induced by IL-15
Concentration:

100, 300, 1000 nM
Incubation Time:

5 days
Result:

Reduced cell number in a dose-dependent manner.

体内実験

Ifidancitinib (10-50 mg/kg, oral, single dose) can induce hair regrowth and reduce associated inflammation in mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C3H/HeJ induced by AA^[2]
Dosage:

10, 25, 50 mg/kg; single dose
0.5g/kg; daily; 12 weeks
Administration:

Oral
Result:

Showed that CD44+CD62L- CD8+ T effector/memory cells were significantly reduced in peripheral blood lymphoid organs of mice, the co-inhibitory receptor PD-1 was highly expressed on effector/memory CD8+ T cells, IFN-γ production was reduced, and γc cytokine regulated T cell exhaustion. Reduced inflammatory infiltrates and inflammatory markers, and the proportion of IFN-γ-producing CD8+ T cells was also significantly reduced.

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 1236667-40-5
性状 Solid
分子量 395.39
分子式 C₂₀H₁₈FN₅O₃
Color Off-white to light yellow
SMILES

O=C1OC2=CC=C(NC3=NC(NC4=CC(C)=C(F)C(OC)=C4)=NC=C3C)C=C2N1
別名

ATI-50002; ATI-502
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Mol Neurobiol

Pharmacological Inhibition of JAK/STAT-IL2 Axis Alleviated Cisplatin-Induced Ototoxicity. [Abstract]

2025 Nov 19;63(1):83. PMID: 41254428

溶剤 & 溶解度

体外:

DMSO : 62.5 mg/mL (158.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5291 mL

12.6457 mL

25.2915 mL

5 mM

0.5058 mL

2.5291 mL

5.0583 mL

10 mM

0.2529 mL

1.2646 mL

2.5291 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Li, Hui; Heckrodt, Thilo J.; Chen, Yan; Mcmurtrie, Darren John; Taylor, Vanessa; Singh, Rajinder; Ding, Pingyu; Yen, Rose.Preparation of phenylaminopyrimidinylaminooxobenzooxazole derivatives for use as JAK kinase inhibitors. WO2012015972A1

[2]. Zhenpeng Dai, et al. Induction of T cell exhaustion by JAK1/3 inhibition in the treatment of alopecia areata. Front Immunol. 2022 Sep 20:13:955038. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5291 mL	12.6457 mL	25.2915 mL	63.2287 mL
	5 mM	0.5058 mL	2.5291 mL	5.0583 mL	12.6457 mL
	10 mM	0.2529 mL	1.2646 mL	2.5291 mL	6.3229 mL
	15 mM	0.1686 mL	0.8430 mL	1.6861 mL	4.2152 mL
	20 mM	0.1265 mL	0.6323 mL	1.2646 mL	3.1614 mL
	25 mM	0.1012 mL	0.5058 mL	1.0117 mL	2.5291 mL
	30 mM	0.0843 mL	0.4215 mL	0.8430 mL	2.1076 mL
	40 mM	0.0632 mL	0.3161 mL	0.6323 mL	1.5807 mL
	50 mM	0.0506 mL	0.2529 mL	0.5058 mL	1.2646 mL
	60 mM	0.0422 mL	0.2108 mL	0.4215 mL	1.0538 mL
	80 mM	0.0316 mL	0.1581 mL	0.3161 mL	0.7904 mL
	100 mM	0.0253 mL	0.1265 mL	0.2529 mL	0.6323 mL

Keywords

Ifidancitinib

1 Cited Publications

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Ifidancitinib

Epigenetics Compound Library

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Stem Cell Signaling Compound Library

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Anti-Rheumatic Arthritis Compound Library

Posttranslational Modification Library

MedChemExpress（MCE）の使用を引用している文献 Ifidancitinib

JAK アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (1)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Ifidancitinib 関連分類

HY-109178 関連分類