インジカン
Based on 1 Customer Validation
Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS). IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.78%
- CAS 番号: 487-60-5
- 分子式: C14H17NO6
- 分子量:295.29
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Spraguee Dawley rats weighing 330-400 g[1]
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Dosage:20, 40 mg/kg
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Administration:Orally
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Result:Increased the systemic exposure and multidrug resistance-associated protein (MRP) of Methotrexate (MTX; 5.0 mg/kg).
化学情報
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CAS 番号 487-60-5
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性状 Solid
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分子量 295.29
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分子式 C14H17NO6
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Color Off-white to light yellow
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SMILES
O[C@@H]1[C@H](O[C@H]([C@@H]([C@H]1O)O)OC2=CNC3=C2C=CC=C3)CO
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別名
Indican; Indoxyl-β-D-glucoside; 3-インドール-D-グルコシド
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (338.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Methanol : 83.33 mg/mL (282.20 mM; Need ultrasonic)
H2O : 20 mg/mL (67.73 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Shiuan-Pey Lin, et al. Transporter-mediated interaction of indican and methotrexate in rats. J Food Drug Anal. 2018 Apr;26(2S):S133-S140. [Content Brief]
[2]. Yu-Chi Hou, et al. Indoxyl sulfate, a uremic toxin, is biotransformed from indoxyl-beta-D-glucoside (indican) in rats. Toxicon. 2008 Sep 1;52(3):440-4. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / Methanol / DMSO | 1 mM | 3.3865 mL | 16.9325 mL | 33.8650 mL | 84.6625 mL |
| 5 mM | 0.6773 mL | 3.3865 mL | 6.7730 mL | 16.9325 mL | |
| 10 mM | 0.3387 mL | 1.6933 mL | 3.3865 mL | 8.4663 mL | |
| 15 mM | 0.2258 mL | 1.1288 mL | 2.2577 mL | 5.6442 mL | |
| 20 mM | 0.1693 mL | 0.8466 mL | 1.6933 mL | 4.2331 mL | |
| 25 mM | 0.1355 mL | 0.6773 mL | 1.3546 mL | 3.3865 mL | |
| 30 mM | 0.1129 mL | 0.5644 mL | 1.1288 mL | 2.8221 mL | |
| 40 mM | 0.0847 mL | 0.4233 mL | 0.8466 mL | 2.1166 mL | |
| 50 mM | 0.0677 mL | 0.3387 mL | 0.6773 mL | 1.6933 mL | |
| 60 mM | 0.0564 mL | 0.2822 mL | 0.5644 mL | 1.4110 mL | |
| Methanol / DMSO | 80 mM | 0.0423 mL | 0.2117 mL | 0.4233 mL | 1.0583 mL |
| 100 mM | 0.0339 mL | 0.1693 mL | 0.3387 mL | 0.8466 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Indican 関連分類
HY-122009 関連分類
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