IQ-1S
Based on 1 publication(s) in Google Scholar
IQ-1S is a prospective inhibitor of NF-κB/activating protein 1 (AP-1) activity with an IC50 of 1.8 μM. IQ-1 has binding affinity (Kd values) in the nanomolar range for all three JNKs with Kds of 87 nM, 360 nM, and 390 nM for JNK3, JNK2, and JNK1, respectively.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1421610-21-0
- 分子式: C15H8N3NaO
- 分子量:269.23
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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MedChemExpress（MCE）の使用を引用している文献 IQ-1S
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生物活性
製品説明
IC50 & Target
[1]|
JNK3 87 nM (Kd) |
JNK2 360 nM (Kd) |
JNK1 390 nM (Kd) |
PI3Kγ 1.2 μM (Kd) |
CK1δ 1.4 μM (Kd) |
MKNK2 1.8 μM (Kd) |
体外実験
IQ-1S (The sodium salt of IQ-1) is a potent, noncytotoxic inhibitor of pro-inflammatory cytokine [IL-1α, IL-1β, IL-6, IL-10, TNF-α, interferon-γ, and GM-CSF)] and nitric oxide production by human and murine monocyte/macrophages. The effect of IQ-1 is evaluated on LPS-induced cytokine production in human PBMCs. Among the 12 cytokines analyzed, LPS (200 ng/mL) consistently induces five (IL-1α, IL-1β, IL-6, IL-10, and TNF-α) in PBMCs compared with DMSO-treated control cells. Production of all of these cytokines is significantly inhibited by 20 μM IQ-1. Among them, TNF-α production is inhibited completely by IQ-1 (>99%), the levels of IL-1α, IL-1β, and IL-10 are decreased by 85%, and IL-6 production is decreased by 33%. IQ-1S inhibits LPS-induced TNF-α and IL-6 production in MonoMac-6 cells with IC50 values of 0.25 and 0.61 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1421610-21-0
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分子量 269.23
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分子式 C15H8N3NaO
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SMILES
[Na]O/N=C1C2=C(C3=NC4=CC=CC=C4N=C3\1)C=CC=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
IQ-1S 関連分類
HY-100233A 関連分類
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