KB02
Based on 1 Customer Validation
KB02 is a DCAF16-recruiting ligand that covalently binds to a ligandable cysteine on DCAF16, recruiting the E3 ligase to mediate target protein degradation. KB02 serves as a DCAF16-binding fragment for the synthesis of SHP2 PROTACs.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.89%
- CAS 番号: 62265-73-0
- 分子式: C11H12ClNO2
- 分子量:225.67
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
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DCAF16 |
体外実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa
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Concentration:7.5 μM
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Incubation Time:24 h
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Result:Lacked the capability to induce SHP2 degradation.
Significantly inhibited SK8-induced SHP2 degradation.\nDid not induce SHP2 degradation.
Significantly inhibited SK8-induced SHP2 degradation.
化学情報
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CAS 番号 62265-73-0
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性状 Solid
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分子量 225.67
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分子式 C11H12ClNO2
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Color White to off-white
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SMILES
OC1=CC=C(N(C(CCl)=O)CCC2)C2=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
純度とドキュメンテーション
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データシート (284 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
KB02 関連分類
HY-189472 関連分類
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