Khellin
Based on 2 publication(s) in Google Scholar
Khellin is a furochromone that can be isolated from Ammi visnuga L.. Khellin is an EGFR inhibitor with an IC50 of 0.15 µM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects.
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- 純度: 99.66%
- CAS 番号: 82-02-0
- 分子式: C14H12O5
- 分子量:260.24
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Khellin
MoreEGFR アイソフォーム固有の製品をすべて表示
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生物活性
IC50: 0.15 µM (EGFR)[1]
化学情報
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CAS 番号 82-02-0
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性状 Solid
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分子量 260.24
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分子式 C14H12O5
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Color White to light yellow
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SMILES
O=C1C=C(C)OC2=C(OC)C(OC=C3)=C3C(OC)=C12
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Acta Pharmacol Sin
Selective inhibition of monoamine oxidase B represents a therapeutic strategy for diabetic peripheral neuropathy. [Abstract]2026 Mar 19. PMID: 41857368 -
Int J Mol Sci
In Vivo Chemical Screening in Zebrafish Embryos Identified FDA-Approved Drugs That Induce Differentiation of Acute Myeloid Leukemia Cells. [Abstract]2024 Jul 16;25(14):7798. PMID: 39063039
溶剤 & 溶解度
DMSO : 16.67 mg/mL (64.06 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (278 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Abdel-Sattar S Hamad Elgazwy, et al. Molecular modeling study bioactive natural product of khellin analogues as a novel potential pharmacophore of EGFR inhibitors. J Enzyme Inhib Med Chem. 2013 Dec;28(6):1171-81. [Content Brief]
[2]. A Ubeda, et al. Relaxant actions of khellin on vascular smooth muscle. J Pharm Pharmacol . 1989 Apr;41(4):236-41. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8426 mL | 19.2130 mL | 38.4261 mL | 96.0652 mL |
| 5 mM | 0.7685 mL | 3.8426 mL | 7.6852 mL | 19.2130 mL | |
| 10 mM | 0.3843 mL | 1.9213 mL | 3.8426 mL | 9.6065 mL | |
| 15 mM | 0.2562 mL | 1.2809 mL | 2.5617 mL | 6.4043 mL | |
| 20 mM | 0.1921 mL | 0.9607 mL | 1.9213 mL | 4.8033 mL | |
| 25 mM | 0.1537 mL | 0.7685 mL | 1.5370 mL | 3.8426 mL | |
| 30 mM | 0.1281 mL | 0.6404 mL | 1.2809 mL | 3.2022 mL | |
| 40 mM | 0.0961 mL | 0.4803 mL | 0.9607 mL | 2.4016 mL | |
| 50 mM | 0.0769 mL | 0.3843 mL | 0.7685 mL | 1.9213 mL | |
| 60 mM | 0.0640 mL | 0.3202 mL | 0.6404 mL | 1.6011 mL |
Khellin 関連分類
HY-B1394 関連分類
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