Lecimibide
Lecimibide (DuP 128) is a potent and specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor for antihyperlipidemia research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 130804-35-2
- 分子式: C34H40F2N4OS
- 分子量:590.77
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| J774 | IC50 |
1000 nM
Compound: 1
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Concentration required to inhibit 50% activity of J774 macrophage cholesterol esterification
Concentration required to inhibit 50% activity of J774 macrophage cholesterol esterification
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[PMID: 7707310] |
| Macrophage | IC50 |
1 μM
Compound: table I
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Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) in J774 Macrophage cell culture by using J774 assay.
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) in J774 Macrophage cell culture by using J774 assay.
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10.1016/0960-894X(95)00001-A |
| Macrophage | IC50 |
1 μM
Compound: DuP-128
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Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture
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10.1016/0960-894X(95)00003-C |
体外実験
Lecimibide (DuP 128)(10 μM, 24 h) can inhibit 85% of the cellular esterification reaction in HepG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 130804-35-2
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分子量 590.77
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分子式 C34H40F2N4OS
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SMILES
O=C(NC1=CC=C(F)C=C1F)N(CCCCCSC2=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N2)CCCCCCC
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別名
DuP 128
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. L J Wilcox, et al. Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP. J Lipid Res. 2001 May;42(5):725-34. [Content Brief]
[2]. J R Burnett, et al. Inhibition of cholesterol esterification by DuP 128 decreases hepatic apolipoprotein B secretion in vivo: effect of dietary fat and cholesterol. Biochim Biophys Acta. 1998 Jul 31;1393(1):63-79. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Lecimibide 関連分類
HY-16281 関連分類
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