Lecimibide
Lecimibide (DuP 128) is a potent and specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor for antihyperlipidemia research.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 130804-35-2
- 分子式: C34H40F2N4OS
- 分子量:590.77
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| J774 | IC50 |
1000 nM
Compound: 1
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Concentration required to inhibit 50% activity of J774 macrophage cholesterol esterification
Concentration required to inhibit 50% activity of J774 macrophage cholesterol esterification
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[PMID: 7707310] |
| Macrophage | IC50 |
1 μM
Compound: table I
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Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) in J774 Macrophage cell culture by using J774 assay.
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) in J774 Macrophage cell culture by using J774 assay.
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10.1016/0960-894X(95)00001-A |
| Macrophage | IC50 |
1 μM
Compound: DuP-128
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Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture
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10.1016/0960-894X(95)00003-C |
Lecimibide (DuP 128)(10 μM, 24 h) can inhibit 85% of the cellular esterification reaction in HepG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 130804-35-2
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分子量 590.77
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分子式 C34H40F2N4OS
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SMILES
O=C(NC1=CC=C(F)C=C1F)N(CCCCCSC2=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N2)CCCCCCC
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別名
DuP 128
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. L J Wilcox, et al. Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP. J Lipid Res. 2001 May;42(5):725-34. [Content Brief]
[2]. J R Burnett, et al. Inhibition of cholesterol esterification by DuP 128 decreases hepatic apolipoprotein B secretion in vivo: effect of dietary fat and cholesterol. Biochim Biophys Acta. 1998 Jul 31;1393(1):63-79. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Lecimibide 関連分類
HY-16281 関連分類
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