LT-104A
LT-104A is a potent PDE4 inhibitor that elevates intracellular cAMP levels (EC50 = 1.9 μM) and inhibits PDE4D3 activity (IC50 = 9.3 μM). LT-104A activates the cAMP-PKA-CREB anti-inflammatory signaling pathway and suppresses NF-κB-related gene expression (Il1b and Nos2). LT-104A can be used for inflammation-related disease research.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2574572-03-3
- 分子式: C33H34O7
- 分子量:542.62
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
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PDE4D3 9.3 μM (IC50) |
体外実験
LT-104A (1-30 μM; 24 h) reduces LPS (HY-D1056) -induced Il1b and Nos2 mRNA expression in J774A.1 macrophages[1].
LT-104A (1-30 μM; 24 h) decreases LPS -induced nitric oxide production in J774A.1 macrophages[1].
LT-104A (0.1-30μM; 30 min) increases intracellular cAMP levels in HEK293 cells in a concentration-dependent manner (EC50 = 1.9 μM)[1].
LT-104A (0.1-30 μM; 6 h) enhances CRE-luciferase activity through activation of the cAMP-PKA-CREB signaling pathway in HEK293 cells[1].
LT-104A (0.1-100 μM) inhibits recombinant PDE4D3 enzymatic activity with an IC50 of 9.3 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LPS(1 μg/mL, 24 h)induced J774A.1 macrophages
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Concentration:1 , 3 , 10 , 30 μM
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Incubation Time:30 min before LPS treatment for 24 h.
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Result:Reduced LPS-induced Il1b and Nos2 mRNA expression.
化学情報
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CAS 番号 2574572-03-3
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分子量 542.62
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分子式 C33H34O7
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SMILES
O=C(C1=CC=CC2=C1C=CC=C2)OC[C@@H]3[C@@H](C4=CC=C(OC)C(OC)=C4)OC[C@@H]3CC5=CC=C(OC)C(OC)=C5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
LT-104A 関連分類
HY-179407 関連分類
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