MAAAHR
MAAAHR is a neuroprotective agent. MAAAHR is isolated and purified from C-phycocyanin of Spirulina platensis. MAAAHR induces antioxidant gene expression through activating the Nrf2 signaling pathway. MAAAHR inhibits excessive Autophagy by reducing the expression of proteins such as α-Syn and Parkin. MAAAHR inhibits Apoptosis. MAAAHR scavenges excessive ROS, enhances SOD, CAT, and GSH-Px activities, and reduces protein carbonyl content. MAAAHR inhibits Acetylcholinesterase. MAAAHR protects zebrafish against MPTP (HY-15608)-induced dopaminergic neuronal and neurovascular loss and alleviates motor impairment. MAAAHR can be used for research on Parkinson's disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C26H45N11O7S
- 分子量:655.77
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
α-synuclein アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
[1]|
AChE |
α-synuclein |
体外実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wild-type AB strain and transgenic vmat2:GFP and fli1:GFP strains (embryos)[1]
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Dosage:12.5, 25, and 50 μg mL−1
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Administration:Co-exposure with 70 μM MPTP in E3 culture solution; daily; from 24 hpf to 96 hpf (continued until 144 hpf for behavioral and gene expression assays)
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Result:Completely reversed the MPTP-induced degeneration of DA neurons in a dose-dependent manner.
Reversed the loss of vasculature and disorganized vasculature caused by MPTP.
Significantly increased the average movement speed and total distance traveled compared to the MPTP model group.
Reduced elevated ROS levels, increased SOD, CAT, and GSH-Px activities, and decreased protein carbonyl content, with the highest concentration returning these indicators to normal levels.
Effectively inhibited MPTP-induced cell apoptosis in a concentration-dependent manner.
High doses dose-dependently inhibited AChE activity.
Reversed the MPTP-induced decrease in nrf2, gclc, gclm, ho-1, and nqo-1, and the increase in keap1.
Reversed the MPTP-induced increases in autophagy-related genes (α-syn, parkin, beclin1, atg5, map1lc3b, atg3) and apoptosis-related genes (caspase-1, caspase-3, caspase-8, caspase-9, bax).
- RT-PCR
- RNA extraction experimental
- Annexin V plus membrane-impermeant dye apoptosis staining
- ROS/oxidative-stress fluorescent staining
- Real Time qPCR (Q-PCR)
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Human pluripotent stem cell midbrain dopaminergic neuron differentiation
- Autophagy
- Apoptosis Solutions
- Lysosome and acidic-vesicle live-cell staining
- Mitophagy Solutions
- Macroautophagy Solutions
化学情報
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分子量 655.77
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分子式 C26H45N11O7S
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SMILES
O=C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)[C@H](CCSC)N
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配列
Met-Ala-Ala-Ala-His-Arg
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シーケンスの短縮
MAAAHR
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MAAAHR 関連分類
HY-P12279 関連分類
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Keywords
- MAAAHR
- Keap1-Nrf2
- α-synuclein
- PINK1/Parkin
- Autophagy
- Apoptosis
- Reactive Oxygen Species (ROS)
- SOD
- Glutathione Peroxidase
- Cholinesterase (ChE)
- zebrafish
- oxidative stress
- Spirulina platensis
- Parkinson's disease
- MPTP
- dopaminergic neurons
- Nrf2 signaling pathway
- autophagy
- apoptosis
- acetylcholinesterase inhibitor
- Inhibitor
- inhibitor
- inhibit