Mefenamic acid-d4
Based on 1 Customer Validation
Mefenamic acid-d4 is a deuterium labeled Mefenamic acid. Mefenamic acid is a BBB-permeable non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.0%
- CAS 番号: 1216745-79-7
- 分子式: C15H11D4NO2
- 分子量:245.31
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
hCOX-1 40 nM (IC50) |
hCOX-2 3 nM (IC50) |
アプリケーション
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
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CAS 番号 1216745-79-7
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非標識Cas 61-68-7
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性状 Solid
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分子量 245.31
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分子式 C15H11D4NO2
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Color White to off-white
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SMILES
O=C(O)C1=C(NC2=CC=CC(C)=C2C)C([2H])=C([2H])C([2H])=C1[2H]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : ≥ 100 mg/mL (407.65 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 0.1 mg/mL (0.41 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Gierse JK, et al. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995 Jan 15;305 (Pt 2):479-84. [Content Brief]
[2]. Hashemipour MA, et al. In Vitro Cytotoxic Effects of Celecoxib, Mefenamic Acid, Aspirin and Indometacin on Several Cells Lines. J Dent (Shiraz). 2016 Sep;17(3):219-25. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 4.0765 mL | 20.3824 mL | 40.7647 mL | 101.9119 mL |
| 5 mM | 0.8153 mL | 4.0765 mL | 8.1529 mL | 20.3824 mL | |
| 10 mM | 0.4076 mL | 2.0382 mL | 4.0765 mL | 10.1912 mL | |
| 15 mM | 0.2718 mL | 1.3588 mL | 2.7176 mL | 6.7941 mL | |
| 20 mM | 0.2038 mL | 1.0191 mL | 2.0382 mL | 5.0956 mL | |
| 25 mM | 0.1631 mL | 0.8153 mL | 1.6306 mL | 4.0765 mL | |
| 30 mM | 0.1359 mL | 0.6794 mL | 1.3588 mL | 3.3971 mL | |
| 40 mM | 0.1019 mL | 0.5096 mL | 1.0191 mL | 2.5478 mL | |
| 50 mM | 0.0815 mL | 0.4076 mL | 0.8153 mL | 2.0382 mL | |
| 60 mM | 0.0679 mL | 0.3397 mL | 0.6794 mL | 1.6985 mL | |
| 80 mM | 0.0510 mL | 0.2548 mL | 0.5096 mL | 1.2739 mL | |
| 100 mM | 0.0408 mL | 0.2038 mL | 0.4076 mL | 1.0191 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mefenamic acid-d4 関連分類
HY-B0574S 関連分類
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