Mipomersen
Based on 3 publication(s) in Google Scholar
Mipomersen (ISIS 301012 free base) is an antisense oligonucleotide inhibitor of apolipoprotein B (apoB). Mipomersen has anti-HCV effect and reduces the infectivity of the HCV. Mipomersen can be used for the research of homozygous familial hypercholesterolemia (HoFH).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 96.88%
- CAS 番号: 1000120-98-8
- 分子量:7179.15
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保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Mipomersen
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Customer Validation & Images
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Cell Proliferation/Viability Assay
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Cell Proliferation/Viability Assay
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ELISA
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Cell Imaging/Staining
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WB
生物活性
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apoB |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Transgenic mice overexpressing human apolipoprotein B-100 (h-apoB mice) or h-apoB-100 plus human apo(a) (Lp(a) mice)[1]
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Dosage:25 mg/kg
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Administration:Intraperitoneal injection; 25 mg/kg, twice weekly for 11 weeks
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Result:Time-dependently reduced the level of h-apoB-100 in Lp(a) mice and h-apoB in h-apoB mice.
化学情報
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CAS 番号 1000120-98-8
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性状 Solid
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分子量 7179.15
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Color White to off-white
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SMILES
[Mipomersen]
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別名
ISIS 301012 free base
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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Poult Sci
Heat stress enhances VLDL secretion in chicken ovarian follicles to potentiate its impact on follicular cell survival and maturation. [Abstract]2025 Nov 19;105(1):106137. PMID: 41349489
Mipomersen purchased from MedChemExpress. Usage Cited in: Poult Sci. 2025 Nov 19;105(1):106137. [Abstract]
Effects of Lomitapide and Mipomersen on granulosa and theca cell viability under heat stress. Granulosa and theca cells were treated with Lomitapide (Lom) and Mipomersen (Mip) (2.5 μM for each) for 2 hr. After washout, cells were heat-stressed (HS, 42°C) for 3 h (3H) and allowed recovery for 13 hr (3H13R). Cells collected at indicated time points were used for viability analysis. *; significant effect by HS (vs. NC within the same pharmacological treatment at the same time point), #; significant effect by time (vs. 3H within the same thermal and pharmacological treatment), +; significant effect by Lom+Mip (vs. vehicle of the same thermal treatment at the same time), P < 0.05, n = 3.
Mipomersen purchased from MedChemExpress. Usage Cited in: Poult Sci. 2025 Nov 19;105(1):106137. [Abstract]
Effects of Lomitapide and Mipomersen on granulosa and theca cell viability under heat stress. Granulosa and theca cells were treated with Lomitapide (Lom) and Mipomersen (Mip) (2.5 μM for each) for 2 hr. After washout, cells were heat-stressed (HS, 42°C) for 8 hr (8H) and allowed recovery for 8 hr (8H8R). Cells collected at indicated time points were used for viability analysis. *; significant effect by HS (vs. NC within the same pharmacological treatment at the same time point), #; significant effect by time (vs. 8H within the same thermal and pharmacological treatment), +; significant effect by Lom+Mip (vs. vehicle of the same thermal treatment at the same time), P < 0.05, n = 3.
Mipomersen purchased from MedChemExpress. Usage Cited in: Poult Sci. 2025 Nov 19;105(1):106137. [Abstract]
Granulosa and theca cells were treated with Lomitapide (Lom) and Mipomersen (Mip) (MTTP and ApoB inhibitor, respectively, 2.5 μM for each) for 2 hr. After washout, cells were heat-stressed (HS, 42°C) for 3 hr (3H) and allowed recovery at 37°C for 13 hr (3H13R). Cells maintained at 37°C served as a neutral control (16H NC). Medium were collected for VLDL isolation and then used for VLDL-apoB determination through the ELISA method.
Mipomersen purchased from MedChemExpress. Usage Cited in: Poult Sci. 2025 Nov 19;105(1):106137. [Abstract]
Effects of Lomitapide and Mipomersen on neutral lipid and cholesterol content of granulosa and theca cells under heat stress. Granulosa and theca cells were treated with Lomitapide (Lom) and Mipomersen (Mip) (2.5 μM for each) for 2 hr. After washout, cells were heat-stressed (HS, 42°C) for 3 (3H) and allowed recovery for 13 (3H13R). Cells collected at indicated time points were used for neutral lipid staining by BODIPYTM493/503 and for cholesterol content determination using commercial kits.
Mipomersen purchased from MedChemExpress. Usage Cited in: Poult Sci. 2025 Nov 19;105(1):106137. [Abstract]
Effects of Lomitapide and Mipomersen on cell proliferation and inflammatory response of granulosa and theca cells under heat stress. Granulosa and theca cells were treated with Lomitapide (Lom) and Mipomersen (Mip) (2.5 μM for each) for 2 hr. After washout, cells were heat-stressed (HS, 42°C) for 3 hr (3H) and allowed recovery for 13 (3H13R). Cells collected at indicated time points were used for PCNA (proliferating cell nuclear antigen) and IL-1β (interleukin-1β) expression through Western blot analysis. Results were normalized to β-actin and expressed as ratios relative to the control (NC 16H or NC 8H).
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Poult Sci
Ovarian expression of functional MTTP and apoB for VLDL assembly and secretion in chickens. [Abstract]2025 Mar 6;104(5):104993. PMID: 40073639 -
J Therm Biol
Functional MTTP and apoB for VLDL secretion in chicken ovaries support small follicle development under heat stress. [Abstract]2025 Oct:133:104298. PMID: 41151185
溶剤 & 溶解度
H2O : ≥ 100 mg/mL (13.93 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (252 KB)
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取扱説明書 (2242 KB)
参考文献
[1]. Merki E, et al. Antisense oligonucleotide directed to human apolipoprotein B-100 reduces lipoprotein(a) levels and oxidized phospholipids on human apolipoprotein B-100 particles in lipoprotein(a) transgenic mice. Circulation. 2008 Aug 12;118(7):743-53. [Content Brief]
[2]. Schaefer EA, et al. Apolipoprotein B100 is required for hepatitis C infectivity and Mipomersen inhibits hepatitis C. World J Gastroenterol. 2016 Dec 7;22(45):9954-9965. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 0.1393 mL | 0.6965 mL | 1.3929 mL | 3.4823 mL |
| 5 mM | 0.0279 mL | 0.1393 mL | 0.2786 mL | 0.6965 mL | |
| 10 mM | 0.0139 mL | 0.0696 mL | 0.1393 mL | 0.3482 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mipomersen 関連分類
HY-148647 関連分類
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