MIPS3526
MIPS3526 is a potent and selective A2B adenosine receptor (A2BR) agonist with a pEC50 of 10.17 (EC50 of 58 pM). MIPS3526 shows highly receptor subtype selective versus the A1R, A2AR, and A3R. MIPS3526 ameliorates angiotensin II stimulating effects in both cardiac myocytes and fibroblasts. MIPS3526 can be used for the study of cardiovascular disease including heart failure where cardiac remodeling is a major driver.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C44H43F3N10O5S
- 分子量:880.94
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Adenosine Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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A2BR 10.24 (pEC50) |
A2BR 58 pM (EC50) |
A1AR 7.08 (pEC50) |
A2AR 6.72 (pEC50) |
A3R 5.48 (pEC50) |
MIPS3526 (compound 7; 1-10 μM) ameliorates angiotensin II-induced neonatal rat cardiomyocyte (NCM) hypertrophywas[1].
\r\nMIPS3526 (1-10 μM) attenuates TGFβ-stimulated collagen synthesis in cardiac fibroblasts[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 880.94
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分子式 C44H43F3N10O5S
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SMILES
NC(S1)=C(C(C2=CC=CC=C2)=O)C(C3=CC(C(F)(F)F)=CC=C3)=C1C(C=C4)=CC=C4C(N=N5)=CN5CCCCCCNC6=NC=NC7=C6N=CN7[C@@H]8O[C@H](C(NCC)=O)[C@@H](O)[C@H]8O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MIPS3526 関連分類
HY-179277 関連分類
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