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NADPH

20 Cited Publications
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NADPH is a coenzyme of glutathione reductase (GR), thioredoxin reductase (TrxR) and NADPH oxidase (NOX), and participates in redox reactions as a hydrogen donor. NADPH has the characteristic of selectively participating in the regulation of cellular redox homeostasis. NADPH exerts antioxidant activity and resists reactive oxygen species (ROS) damage by providing reducing equivalents for the regeneration of glutathione (GSH) and thioredoxin (Trx); at the same time, it acts as a substrate of NOX to generate superoxide anions, mediating oxidative stress and immune response. NADPH participates in maintaining the intracellular reducing environment, biosynthesis and regulating gene expression (such as the Nrf2 pathway), and is mainly used in the study of oxidative stress-related diseases (such as cardiovascular diseases, neurodegenerative diseases, cancer) and immune regulation mechanisms.

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  • 純度: 99.75%
  • CAS 番号: 53-57-6
  • 分子式: C21H30N7O17P3
  • 分子量:745.42
  • 保管条件:

    4°C, protect from light

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

  • NADPH Chemical Structure
    NADPH 構造式
  • Experimental Validation Results for NADPH
  • Experimental Validation Results for NADPH
  • Experimental Validation Results for NADPH
  • Experimental Validation Results for NADPH
  • Experimental Validation Results for NADPH
  • Experimental Validation Results for NADPH
CAS 番号: 53-57-6
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  • NADPH Chemical Structure
    NADPH Chemical Structure
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  • 1/16

    NADPH purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 15:e07283. [Abstract]

    Customer Validation
     A normal cellular state was recovered by adding TEMPO or NADPH (1mM, 24h), or SLC7A11 knockdown.

  • 1/16

    NADPH purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 15:e07283. [Abstract]

    Customer Validation
     Western Blot analysis of RAC/WAVE pathway-related indicators in vitro skeletal muscle cells. Muscle cells treated with different condition NADPH(1mM, 24h).

  • 1/16

    NADPH purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 15:e07283. [Abstract]

    Customer Validation
     mtROS fluorescence staining of skeletal muscle cells in vitro. Muscle cells treated with different condition NADPH(1mM, 24h).

  • 1/16

    NADPH purchased from MedChemExpress. Usage Cited in: Mol Plant Pathol. 2025 Dec;26(12):e70196. [Abstract]

    Customer Validation
     Enzymatic activities of AtCAD7, AtCAD5, EcYahK, and EcYjgB toward (Z)‐3‐hexenal, acrolein, isovaleraldehyde, salicylaldehyde, and p‐coumaryl aldehyde. No Substrate was negative control. Assays were conducted under standardised conditions (30°C, pH 6.5, 100 μM substrate, 200 μM NADPH).

  • 1/16

    NADPH purchased from MedChemExpress. Usage Cited in: Mol Ther Oncol. 2024 Sep 17;32(4):200878. [Abstract]

    Customer Validation
     Apoptosis proportion of oncoVV-AVL-treated AsPC-1(Up) and PANC-1 (Down) cells treated with NADPH (300 μM) or NADH. Data are presented as the mean ± SD (n=3).

  • 1/16

    NADPH purchased from MedChemExpress. Usage Cited in: Mol Ther Oncol. 2024 Sep 17;32(4):200878. [Abstract]

    Customer Validation
     Western blotting detection of the expressions of caspase-3 and caspase-9 in oncoVV or oncoVV-AVL-treated AsPC-1(Up) and PANC-1 (Down) cells treated with NADPH (300 μM).

  • NADPH