Nebratamig
Based on 1 Customer Validation
Nebratamig (GNC-035) is an anti-ROR1/anti-CD3/anti-PD-L1/anti-4-1BB tetra-specific antibody with potential immunostimulatory and antineoplastic activities.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 97.34%
- CAS 番号: 2694723-68-5
- 分子量:302.32 kDa
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
(scFv-kappa-heavy)-G1_L-kappa-(scFv-heavy-kappa)-(scFv-heavy-kappa)
Human
CD3 & TNFRSF9 & CD274 & ROR1
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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scFv-G1K-scFv-scFv_kappa
ELISA, FACS, Functional assay
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Immobilized ROR1 Protein, Human (HEK293, His, HY-P70317) can bind Nebratamig. The EC50 for this effect is 8.808 ng/mL. -
Immobilized CD3 epsilon Protein, Human (HEK293, His, HY-P70506) can bind Nebratamig. The EC50 for this effect is 25.92 ng/mL. -
Immobilized 4-1BB/TNFRSF9 Protein, Human (HEK293, His, HY-P70678) can bind Nebratamig. The EC50 for this effect is 8.016 ng/mL. -
Immobilized PD-L1 Protein, Human (HEK293, HY-P73361) can bind Nebratamig. The EC50 for this effect is 14.78 ng/mL. -
Flow cytometric analysis of 1×106 Jurkat cells labelling CD3 (red) with Nebratamig (HY-P991209). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
化学情報
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CAS 番号 2694723-68-5
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性状 Liquid
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分子量 302.32 kDa
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Color Colorless to light yellow
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SMILES
[Nebratamig]
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別名
GNC-035
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (255 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)