Nigranoic acid
Based on 1 Customer Validation
Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 95.0%
- CAS 番号: 39111-07-4
- 分子式: C30H46O4
- 分子量:470.68
-
保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
HY-10574
RilpivirineNNRTI -
HY-90005
Etravirine -
HY-B1826
AdefovirHBV Inhibitor -
HY-15232A
Tenofovir alafenamide fumarateReverse Transcriptase Inhibitor -
HY-104012
IslatravirNucleoside Reverse Transcriptase Translocation Inhibitor -
HY-16767
DoravirineNNRTI -
HY-15232B
Tenofovir alafenamide hemifumarateReverse Transcriptase Inhibitor -
HY-120097
R-10015LIMK Inhibitor -
HY-147411
UlonivirineHIV-1 reverse transcriptase Inhibitor -
HY-122470
StampidineNRTI -
HY-70083
SPK-601PC-PLC Inhibitor -
HY-15336
AG 555EGFG Inhibitor
生物活性
製品説明
IC50 & Target
HIV-1 reverse transcriptase
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| C8166 | CC50 |
88 μg/mL
Compound: 3
|
Cytotoxicity against human C8166 cells by MTT assay
Cytotoxicity against human C8166 cells by MTT assay
|
[PMID: 16499331] |
| C8166 | EC50 |
10.3 μg/mL
Compound: 3
|
Antiviral activity against HIV1 infected in human C8166 cells assessed as inhibition of viral-induced cytopathic effect
Antiviral activity against HIV1 infected in human C8166 cells assessed as inhibition of viral-induced cytopathic effect
|
[PMID: 16499331] |
体内実験
Nigranoic acid (1 mg/kg; i.g.; 6 hours and 2 hours before brain ischemia) significantly decreases apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Sprague–Dawley rats (200-300 g), ischemia–reperfusion model[2]
-
Dosage:1 mg/kg
-
Administration:Intragastric; 6 hours and 2 hours before brain ischemia
-
Result:Decreased apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points.
化学情報
-
CAS 番号 39111-07-4
-
性状 Solid
-
分子量 470.68
-
分子式 C30H46O4
-
Color Off-white to light yellow
-
SMILES
OC(CC[C@@]12[C@]3([C@](CC[C@H]2C(C)=C)([H])[C@]4([C@@](C)([C@]([C@H](C)CC/C=C(C)\C(O)=O)([H])CC4)CC3)C)C1)=O
-
Structure Classification
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
-
データシート (268 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Sun HD, et al. Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase. J Nat Prod. 1996 May;59(5):525-7. [Content Brief]
[2]. Feng T, et al. Protective effects of nigranoic acid on cerebral ischemia-reperfusion injury and its mechanism involving apoptotic signaling pathway. Cell Biochem Biophys. 2015 Jan;71(1):345-51. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Nigranoic acid 関連分類
HY-122935 関連分類
Powered by Bioz